桂枝茯苓丸联合达那唑对子宫内膜异位症患者血清VEGF Flk-1和炎性因子水平的影响  

Effect of Guizhi Fuling Pill Combined with Albendazole on Serum VEGF and Flk-1 and Inflammatory Factors Levels of Patients with Endometriosis

作　　者：雷侠[1] 王媛[1] 师晓艳[1] 王延明[1] 卢秀琴[1] LEI Xia;WANG Yuan;SHI Xiaoyan;WANG Yanming;LU Xiuqin(The Affiliated Hospital of Yan'an University,Shaanxi Yanan 716000,China)

机构地区：[1]延安大学附属医院妇科,陕西延安716000

出　　处：《河北医学》2018年第3期492-495,共4页Hebei Medicine

基　　金：陕西省自然科学基金;(编号:2006k09-G14)

摘　　要：目的:观察桂枝茯苓丸和达那唑联合治疗子宫内膜异位症(EMs)的临床效果及对其血清血管内皮生长因子(VEGF)、胎肝激酶(Flk)-1、炎性因子水平的影响。方法:选取2015年2月至2016年12月116例EMs患者,采用随机数字表法均分为两组。对照组给予达那唑治疗,观察组给予桂枝茯苓丸和达那唑联合治疗。比较两组治疗后临床综合疗效,治疗前后血清VEGF、Flk-1、炎性因子水平及不良反应的发生情况。结果:治疗后,观察组总有效率较对照组明显上升(P<0.05)。与治疗前相比,两组治疗后血清VEGF、Flk-1、IL-6、IL-8、CRP水平均显著下降(P<0.01),且观察组以上指标均显著低于对照组(P<0.01)。两组不良反应发生率相比差异无统计学意义(P>0.05)。结论:桂枝茯苓丸和达那唑联合治疗子宫内膜异位症能显著提高其临床疗效且安全性高,可能与其有效降低患者血清VEGF、Flk-1和炎性因子水平有关。Objective:To explore the clinical efficacy of Guizhi fuling capsules combined with albendazole in the treatment of endometriosis(EMT)and effects on the serum levels of vascular endothelial growth factor(VEGF),fetal liver kinase(Flk-1)and inflammatory factors.Methods:116 patients with EMT admitted in our hospital from February 2015 to December 2016 were selected and randomly divided into two groups.The patients in control group were treated with pantoprazole while the patients in the observation group were treated with Guizhi Fuling pill and albendazole.The clinical efficacy,the levels of serum VEGF,Flk-1,inflammatory factors before and after treatment and incidence of adverse reactions were compared between two groups.Results:After treatment,the total effective rate of observation group was 93.1%,which was significantly higher than that of the control group(P<0.05).Compared with before treatment,the levels of serum VEGF,Flk-1 IL-6,IL-8 and CRP of two groups after treatment were significantly lower than before(P<0.01),and the observation group were lower than those of the control group(P<0.01).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Guizhi Fuling pill combined with albendazole can effectively enhance the clinical efficacy with high safety in the treatment of EMT.It may be related to the decrease of serum VEGF,Flk-1 and inflammatory factors levels.

关 键 词：子宫内膜异位症 桂枝茯苓丸 血管内皮生长因子 胎肝激酶-1 炎性因子 

分 类 号：R711.71[医药卫生—妇产科学]