^(18)F-FDG符合线路SPECT-CT显像靶与非靶比值在肿瘤诊疗中的应用  

The application of target to non-target ratio in ^(18)F-FDG SPECT-CT coincidence imaging for the diagnosis of tumor

作　　者：李楠[1,2] 章斌 邓胜明[1] LI Nan;ZHANG Bin;DENG Sheng-ming

机构地区：[1]苏州大学附属第一医院核医学科,江苏苏州215006 [2]常州市肿瘤(第四人民)医院核医学科,江苏常州213001

出　　处：《中国医学装备》2018年第4期120-124,共5页China Medical Equipment

摘　　要：单光子发射型电子计算机断层扫描仪-X射线计算机断层扫描仪(SPECT-CT)将CT与SPECT有机整合,并能使用^(18)F-氟脱氧葡萄糖(^(18)F-FDG)进行符合线路显像,一次显像能同时获得SPECT的功能代谢和CT的解剖诊断信息图像,还能够计算相对半定量分析指标靶与非靶(T/NT)比值,是目前肿瘤诊疗的重要影像学手段之一。但是对于T/NT比值在肿瘤诊断中鉴别良恶性的界值以及NT的感兴趣区(ROI)选取部位,还缺乏公认的标准。如果参考T/NT≥2.5为恶性肿瘤诊断阈值,可能存在一定的假阳性与假阴性。故对符合线路-CT显像的T/NT比值ROI选取部位及影响因素、诊断肿瘤良恶性的界值及其在肿瘤诊疗中的应用进展进行综述,证实增加了CT功能的符合线路显像的增益价值在于,可从解剖学上更加精确地寻找病灶,也为计算T/NT比值时ROI的勾画提供更加准确的定位信息,从而为临床活检、手术或放射治疗靶区的勾画等提供更有用的影像资料。SPECT-CT integrates CT with SPECT,and can use 18F-fluorodeoxyglucose(FDG)for coincidence imaging.Its imaging can simultaneously indicate the function metabolism information from SPECT and the diagnostic information about anatomy from CT.And the target to no-target(T/NT)ratio can be calculated by using relative semi-quantitative analysis after once imaging.So SPECT-CT is one of the important imaging methods of tumor diagnosis and treatment.However,there is no accepted standard about cut-off level of T/NT ratio in the diagnosis for tumor,also about the selection location of region of interest(ROI)when you calculated the T/NT ratio.If T/NT ratio≥2.5 was referred as threshold in the diagnose of malignant tumor,there may be some false positive and false negative.This paper reviews the methods of the selection location of ROI for T/NT ratio in coincidence-CT imaging,and its influence factors,and its value of the diagnosis for benign malignancy,as well as its application progress in tumor diagnosis and treatment.It proves that the increased value by CT to the pure SPECT imaging is that it can more accurately detect lesions anatomically.By the way,it provide more accurate positioning information for the rang of ROI.Thereby,it provide more useful imaging information for clinical biopsy,surgery or the rang of radiotherapy target area.

关 键 词：放射性核素体层摄影术 单光子发射型计算机 体层摄影术 X射线计算机断层扫描仪 氟脱氧葡萄糖 肿瘤 靶与非靶比值 

分 类 号：R816[医药卫生—放射医学]