细菌溶血素毒性和致病机制研究进展  

Advance in toxic and pathogenic mechanisms of bacterial hemolysins

作　　者：马碧书 马丽娜 林旭瑷[3] 严杰[3] MA Bi-shu;MA Li-na;LIN Xu-ai;YAN Jie(Department of Microbiology and Immunology,Haiyuan College of Kunming Medical University, Kunming 650106,China;College of Medical Technology,Gansu Chinese Medical University,Lanzhou 743000,China;Department of Microbiology and Parasitology,School of Medicine,Zhejiang University, Hangzhou 310058,China)

机构地区：[1]昆明医科大学海源学院微生物学和免疫学教研室,昆明650106 [2]甘肃中医药大学医学技术学院,兰州743000 [3]浙江大学医学院病原生物学系,杭州310058

出　　处：《中国人兽共患病学报》2018年第2期175-181,共7页Chinese Journal of Zoonoses

基　　金：国家自然科学基金(No.30700034);浙江省自然科学基金(No.LY17H190002)联合资助~~

摘　　要：许多病原菌能产生溶血素溶解红细胞,但近年发现细菌溶血素还能损伤或致死多种有核细胞和血小板。根据分子结构、结合细胞方式、膜孔道形成机制等不同,可将大多数细菌溶血素分类为重复子毒素家族(repeats in toxin family,RTX)和胆固醇依赖细胞溶素家族(cholesterol-dependent cytolysin family,CDC)毒素。细菌溶血素可通过膜损伤、细胞溶解或裂解、离子失衡相关病变、细胞凋亡或坏死性凋亡以及TLR2/4介导的NF-κB、p38MAPK、JNK信号传导通路和NLRs介导的NLRP3炎症小体引发强烈的炎症反应并导致炎症性组织损伤,从而在细菌感染过程中发挥重要致病作用。Many bacterial pathogens can produce hemolysins to lyse erythrocytes,but recent studies revealed that bacterial hemolysins could cause injury and death of many nucleated cells and platelets.According to the difference of molecular structure,cell-binding manner and membrane pore-forming mechanism,most of bacterial hemolysins are classified into the toxins belonging to either repeats in toxin family(RTX)or cholesterol-dependent cytolysin family(CDC).Bacterial hemolysins play important pathogenic roles during infection of bacteria through membrane damage,cell lysis or disruption,ion disequilibrium-associated pathological changes,cell apoptosis or cell necroptosis as well as through TLR2/4-mediated NF-κB,p38MAPK,JNK signaling pathways and NLRs-mediated NLRP3 inflammasomes to cause powerful inflammatory reaction and inflammatory tissue injury.

关 键 词：细菌溶血素 膜损伤 细胞裂解 细胞凋亡 炎症反应 

分 类 号：R378[医药卫生—病原生物学]