人工建立肝脏泡球蚴模型后小鼠的死亡规律和原因分析  

Death pattern and cause analysis in mice after establishment of the liver alveolar hydatid model

作　　者：王岩[1] 苏争明 陈骞[1] 张怀[1] 李江[1] 代平 张示杰[1] WANG Yan;SU Zheng-ming;CHEN Qian;ZHANG Huai;LI Jiang;DAI Ping;ZHANG Shi-jie(Department of Hepatobiliary,the First Affiliated Hospital,Medicine College,Shihezi University,Shihezi 832000,China;Department of Oncology,the First Affiliated Hospital,Medicine College,Shihezi University, Shihezi 832000,China)

机构地区：[1]石河子大学医学院第一附属医院肝胆外科,石河子832000 [2]石河子大学医学院第一附属医院肿瘤内科,石河子832000

出　　处：《中国人兽共患病学报》2018年第3期207-212,共6页Chinese Journal of Zoonoses

基　　金：国家自然科学基金项目(血管新生在肝泡球蚴侵润性生长中的作用机制研究)(No.81560518)资助~~

摘　　要：目的研究人工建立肝脏接种泡球蚴模型后小鼠的死亡规律及主要死亡原因,探讨造模术后导致死亡的主要并发症的风险因素及预防。方法开腹直视肝脏穿刺法接种50只健康昆明小鼠,术后15d内动态观察小鼠的生理变化并记录死亡时间与数量,着重分析其死亡原因及相关因素。结果术后15d共死亡19只,第9d死亡1只,其余18只在术后7d内死亡。术后死亡量于第2d开始上升,第4、5d达高峰后逐渐下降至第7d死亡1只。结论泡球蚴接种术后小鼠的主要死亡原因与手术方式、麻醉、感染、泡球蚴的抗原性、肝损伤等导致的并发症密切相关。有效预防此类并发症是提高造模生存率的关键。We studied the death pattern and the main causes of death after artificial liver inoculation with alveolar hydatid model,and explored the risk factors and prevention of major complications resulting from death after modeling.The 50 healthy Kunming mice were inoculated with open-staring liver puncture and the physiological changes of the mice were observed dynamically within 15 days after operation.The time and amount of death were recorded,and the causes of death and related factors were analyzed emphatically.On the 15 day after surgery,19 died;1 died in the ninth day,and the remaining 18 died within 7 days of the operation.The postoperative death rate began to rise in the second day,and gradually decreased to 1 after the peak of the 4 th and 5 th days.The main causes of death of the mice after inoculation were closely related to the complications of surgical methods,anaesthesia,infection,antigenicity of vesicle,and liver injury.Effective prevention of these complications is the key to improve the survival rate.

关 键 词：泡球蚴 模型 死亡规律 原因分析 

分 类 号：R383.3[医药卫生—医学寄生虫学]