登革病毒感染合并脂肪肝191例肝脏酶学分析  

Liver enzymes of 191 dengue cases with fatty liver

作　　者：崔新国 陈邑洪 周红宁 刘霭迎 张丽红 CUI Xin-guo;CHEN Yi-hong;ZHOU Hong-ning;LIU Ai-ying;ZHANG Li-hong(Yunnan Provincial Key Laboratory of Vector-borne Disease Control and Research&Yunnan Collaborative Innovation Center for Public Health and Disease Prevention and Control;Institution of Pathogens and Vectors,Pu’er Division,Dali University;Yunnan Institution of Parasitic Diseases,Pu’er,6650;The Isolation Hospital of Xishuangbanna Dai Nationality Autonomous Prefecture,Xishuangbanna 666100,China)

机构地区：[1]云南省虫媒传染病防控研究重点实验室,云南省虫媒病毒研究中心,云南省公共卫生协同创新中心,大理大学病原与媒介生物研究所(普洱分部),云南省寄生虫病防治所,普洱665000 [2]云南省西双版纳傣族自治州传染病院,西双版纳666100

出　　处：《中国人兽共患病学报》2018年第3期282-285,共4页Chinese Journal of Zoonoses

基　　金：国家自然科学基金项目(Nos.U1602223，81160357,30960327,30660160)，云南省重大科技(No.2017ZF007)云南公共卫生与疾病防控协同创新中心孵化项目(No.2014YNPHXT03)，中英学者基金资助项目(Sino-British fellowship trust in UK，No.313669)

摘　　要：目的探讨西双版纳州登革热合并脂肪肝病例的肝脏酶学变化特征,为制定当地登革热有效治疗方案提供依据。方法对2013和2015年西双版纳州191例登革病毒感染合并脂肪肝病例临床资料和191例随机对照组进行登革病例主要肝脏酶学指标回顾性分析。结果 191例登革病毒感染合并脂肪肝患者丙氨酸氨基转氨酶增高率为84.8%,天门冬氨酸氨基转氨酶增高率为90.1%,γ-谷氨酰转移酶增高率76.8%和黄疸指数增高率20.4%,除黄疸指数外,其它3个指标均明显高于对照组(P<0.05)。结论西双版纳州登革热病例中合并脂肪肝患者肝损伤严重,其中以丙氨酸氨基转氨酶、天门冬氨酸氨基转氨酶、γ-谷氨酰转移酶增高为主,提示一旦发现登革热患者合并脂肪肝时,临床医师应密切监测患者上述3种酶的变化并及时给予相关治疗。We explored the liver enzymes characteristics of dengue patients with fatty liver in Xishuangbanna,providing evidences for local dengue fever effective treatment program.The clinical data of 191 dengue patients with fatty liver and 191 randomized controls was retrospectively analyzed on the patients’mainly liver enzymes indicators in Xishuangbanna Prefecture from 2013 to 2015.Results showed that the 191 cases with fatty liver,the growth rate of such as alanine aminotransferase was 84.8%,aspartate aminotransferase was 90.1%,gamma glutamyltransferase was 76.8%and bilirubin index was 20.4%,except bilirubin index,the other 3 indicators in dengue patients with fatty liver were higher than those in the control group(P<0.05).The liver injury was serious for the dengue cases with fatty liver in Xishuangbanna,of those alanine aminotransferase,aspartate aminotransferase and gamma glutamyltransferase were significantly increased.These results suggested that doctors should pay attention to above 3 enzymes changes and take related treatments immediately as soon as dengue cases with fatty liver were detected.

关 键 词：登革病毒 肝脏酶学 脂肪肝 西双版纳州 

分 类 号：R373.3[医药卫生—病原生物学]