成人生长激素缺乏症患者脂质蓄积指数与心血管疾病危险因素的相关性分析  

Correlation of lipid accumulation product and cardiovascular risk factors for disease in patients with adult growth hormone deficiency

作　　者：陈维蓓[1] CHEN weibei(Department of Clinical Laboratory,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院检验科,重庆400016

出　　处：《国际检验医学杂志》2018年第7期808-811,814,共5页International Journal of Laboratory Medicine

基　　金：国家临床重点专科建设项目经费资助项目(财社[(2010)305]号)

摘　　要：目的探讨成人生长激素缺乏症(AGHD)患者的脂质蓄积指数(LAP)与心血管疾病危险因素的相关性。方法选取2015-2017年重庆医科大学附属第一医院收治的AGHD患者40例作为AGHD组,另选取同期在体检中心进行体检的40例健康人为对照组,比较两组的一般情况和血生化指标,计算LAP值、胰岛素抵抗指数(HOMA-IR)、胰岛素分泌指数(HOMA-β)、低密度脂蛋白胆固醇(LDL-C)/高密度脂蛋白胆固醇(HDL-C)比值、总胆固醇(TC)/HDL-C比值、三酰甘油(TG)/HDL-C比值并进行组间比较。结果与对照组相比,AGHD组腰围(WC)尺寸、腰臀比(WHR)、HOMA-β、TG、空腹胰岛素(FINS)、LDL-C/HDL-C、TC/HDL-C、HOMA-IR、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、LAP等全部升高,HDL-C明显降低,且差异均有统计学意义(P<0.05);两组年龄、身高、血压、臀围、体质量指数(BMI)、TC、空腹血糖(FPG)、TG/HDL-C、LDL-C水平差异无统计学意义(P>0.05)。LAP值与WC、WHR、FINS、HOMA-β、HOMA-IR、TG、HDL-C、LDL-C/HDL-C、TC/HDL-C、hs-CRP、IL-6呈正相关(P<0.05)。Logistic单因素回归分析显示,FINS、hs-CRP、IL-6、LAP是AGHD的危险因素,HDL-C是其保护因素;多因素回归分析显示,hs-CRP、LAP仍然是AGHD的危险因素,HDL-C仍然是其保护因素。结论 AGHD患者的LAP水平显著高于健康人群,并与罹患心血管疾病的多种危险因素显著相关。Objective To explore the correlation of lipid accumulation product and cardiovascular risk factors for disease in patients with adult growth hormone deficiency.Methods Retrospective analysis was carried out in 40 AGHD patients(AGHD group,admitted to the First Affiliated Hospital of Chongqing Medical University)and 40 healthy adults from physical examination centre(control group)during January 2015 to March 2017.The general anthropometries and blood biochemical indexes were collected and compared between two groups.LAP,homeostasis model assessment-insulin resistance(HOMA-IR),homeostasis model assessmentβ-cell function(HOMA-β),LDL-C/HDL-C,TC/HDL-C and TG/HDL-C were calculated and compared between two groups.Results Compared with control group,body mass index(BMI),waist circumference(WC),wasit-hip ratio(WHR),fastinginsulin(FINS),HOMA-β,HOMA-IR,totalcholesterol(TC),riglyceride(TG),LDL-C/HDL-C,TC/HDL-C,hs-CRP,IL-6,LAP were significantly higher,but HDL-C levels were lower in AGHD group(P<0.05).There were no significant differences in age,height,BIM,hip circumference,blood pressure,fasting plasma glucose(FPG),TC,LDL-C,TG/LDL between two groups(P>0.05).There was a positive association between LAP and all the WC,WHR,FINS,HOMA-β,HOMA-IR,TG,HDL-C,LDL/HDL-C,TC/LDL-C,hs-CRP and IL-6(P<0.05).Logistic regression analysis of single factor indicated that FINS,hs-CRP,IL-6 and LAP were the risk factors of AGHD,HDL-C was the positive factor;logistic regression analysis of multiple factors indicated that hs-CRP and LAP still were the risk factors of AGHD,HDL-C still was the positive factor.Conclusion LAP was significantly higher in AGHD patients than that in healthy people,and it shows a strong correlation with many risk factors for cardiovascular disease.

关 键 词：成人生长激素缺乏症 脂质蓄积指数 心血管危险因素 

分 类 号：R446.1[医药卫生—诊断学]