YP2C19基因多态性与中国北方地区人群缺血性脑卒中氯吡格雷抵抗的相关性研究  

The research of clopidogrel resistance of CYP2C19 gene polymorphisms and the crowd of ischemic cerebral apoplexy in northern China

作　　者：董海荣[1] 徐肖倩 康德成 嘎勒登玛[1] DONG Hairong;XU Xiaoqian;KANG Decheng;GALEDENGMA(Department of Clinical Laboratory,the First Hospital of Hohhot in Inner Mongolia,Hohhot,Inner Mongolia 010030,China;The School of Public Health,Inner Mongolia Medical University,Hohhot,Inner Mongolia 010059,China)

机构地区：[1]呼和浩特市第一医院检验科,内蒙古呼和浩特010030 [2]内蒙古医科大学公共卫生学院,内蒙古呼和浩特010059

出　　处：《国际检验医学杂志》2018年第7期820-823,共4页International Journal of Laboratory Medicine

基　　金：内蒙古自治区科技计划项目(20130423);内蒙古自治区青年创新人才计划

摘　　要：目的调查CYP2C19基因多态性与中国北方人群缺血性脑卒中患者氯吡格雷抵抗(CR)的相关性。方法选取2015年9月至2016年11月入住呼和浩特市第一医院并留取基因血标本、临床诊断为缺血性脑卒中的患者作为研究对象;用Taqman探针法检测CYP2C19基因多态性。结果所研究人群的氯比格雷抵抗的比例为59%,CYP2C19*2突变株与氯比格雷抵抗有强相关性(P=0.006),而且发现糖尿病、高血压、吸烟饮酒、C反应蛋白(CRP)及天门冬氨酸氨基转移酶(AST)增高与氯比格雷抵抗有相关性。结论携带CYP2C19*2等位基因的患者在抗血栓治疗时发生氯比格雷抵抗的风险更大,有糖尿病、高血压、吸烟饮酒史及CRP、AST增高的危险因素患者,发生CR的风险更大。Objective To investigate the correlation between CYP2C19 gene polymorphism and clopidogrel resistance(CR)in patients with ischemic stroke in the north of China.Methods The patients with ischemic stroke were selected as the research object from the First Hospital of Hohhot during September 2015 to November 2016.The polymorphism of CYP2C19 gene was detected by Taqman probe method.Results The clopidogrel resistance ratio of the study population is 59%.There is a strong correlation between the CYP2C19*2 mutant strains with clopidogrel resistance(P=0.006),and we foundd that the increased glutamic oxalacetic transaminase was associated with clopidogrel resistance.Conclusion Patients with the CYP2C19*2 allele were at greater risk of clopidogrel resistance during antithrombotic therapy.

关 键 词：氯吡格雷 单核苷酸多肽性 CYP2C19 

分 类 号：R596.2[医药卫生—内科学] R742[医药卫生—临床医学]