白斑汤联合波姆光治疗肝肾阴虚型外阴硬化性苔藓疗效观察及其对病灶局部CD57蛋白表达的影响  

Effect of Baiban decoction combined with bomu light on vulvar lichen sclerosus of liver-kidney yin deficiency syndrome and CD57 protein expression of lesion location

作　　者：王桂萍[1] 李灵芝[1] 蒋俊青[1] 李智慧 袁世红 

机构地区：[1]天津市中医药研究院附属医院 [2]天津中医药大学研究生院

出　　处：《山西中医》2018年第3期6-10,14,共6页Shanxi Journal of Traditional Chinese Medicine

基　　金：天津市中医药管理局科研项目(编号:2015015)

摘　　要：目的:探讨白斑汤联合波姆光对肝肾阴虚型外阴硬化性苔藓患者证侯改善情况及对病灶局部CD57蛋白表达的影响。方法:80例肝肾阴虚型外阴硬化性患者为研究对象,按照随机数字表将患者分为治疗组和对照组各40例,对照组采用波姆光照射加白斑汤外洗方,治疗组采用白斑汤口服方与波姆光照射加白斑汤外洗方,治疗3个月后,观察两组患者的临床症状改善情况、中医证侯改善情况及局部病灶CD57蛋白的表达。结果:(1)临床疗效方面:治疗组总有效率为95.0%,对照组总有效率为82.5%,两组比较有统计学差异(P<0.05),治疗组疗效优于对照组;治疗组治疗后肝肾阴虚证侯积分明显低于对照组,两组比较有统计学差异(P<0.05)。两组治疗后患者自觉症状、外阴病损程度均有明显改善,与治疗前比较均有统计学差异(P<0.05);且治疗组治疗后患者自觉症状、外阴病损程度改善更加明显,与对照组比较有统计学差异(P<0.05)。(2)实验室指标:CD57^+表达情况比较:两组患者治疗后病损处皮肤CD57^+淋巴细胞表达均明显下降,与治疗前比较差异均有统计学意义(P<0.05);治疗组疗效优于对照组,但差异不具有统计学意义(P>0.05)。(3)安全性评价:两组患者在治疗期间均无不良反应发生。结论:白斑汤联合波姆光照射治疗可以降低外阴硬化性苔藓患者肝肾阴虚症候积分,改善患者自觉症状及局部体征,下调病变局部CD57^+淋巴细胞的表达。Objective:To observe the effect of Baiban decoction combined with bomu light on vulvar lichen sclerosus(LS)of liver-kidney yin deficiency syndrome and CD57 protein expression of lesion location in patients with LS.Methods:80 cases of patients with vulvar lichen sclerosus of liver-kidney yin deficiency syndrome were taken as researched objects and divided randomly into treatment group and control group,40 cases in each group.The control group was treated with bomu light irradiation plus Baiban decoction for external washing,while the treatment group was treated with oral Baiban decoction and bomu light irradiation plus Baiban decoction for external washing.After three months of treatment,the improvement of clinical symptoms and TCM syndromes and the expression of CD57 protein of lesion location of patients were observed in two groups.Results:1.In clinical efficacy:the total effective rate was 95%in treatment group,while 82.5%in control group.There was a statistical difference compared between two groups(P<0.05),and the effect of treatment group was better than that of control group.After treatment,the score of liver-kidney yin deficiency syndrome of treatment group was significantly lower than that of control group,and there was a statistical difference compared between two groups(P<0.05).The subjective symptom and the degree of vulvar pathologic damage of patients in both groups were significantly improved after treatment,and there was a statistical difference compared with before treatment(P<0.05).And the improvement of subjective symptom and degree of vulvar pathologic damage of patients after treatment in treatment group was more significant;compared with control group,there was a statistical difference(P<0.05).2.In laboratory indexes:comparison of CD57+expression:after treatment in patients of both groups,the expression of CD57+lymphocytes in skin lesion was reduced obviously.Compared with before treatment,the difference was statistically significant(P<0.05).The effect of treatment group was better than that

关 键 词：外阴硬化性苔藓 白斑汤 CD57蛋白 

分 类 号：R711.72[医药卫生—妇产科学]