月经状态对乳腺纤维腺体组织与背景实质强化的影响  

Influence of menopause status on breast fibrograndular tissue and background parenchymal enhancement

作　　者：胡晓欣 顾雅佳[1,2] 姜娈 李强[3] 尤超[1,2] 毛健[1,2] 彭卫军 HU Xiao-xin;GU Ya-jia;JIANG Luan;LI Qiang;YOU Chao;MAO Jian;PENG Wei-jun(Department of Radiology,Shanghai Cancer Center,Fudan University,Shanghai 200032,China;Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China;Center for Advanced Medical Imaging Technology,Shanghai Advanced Research Institute,Chinese Academy of Sciences,Shanghai 201210,China)

机构地区：[1]复旦大学附属肿瘤医院放射诊断科,上海200032 [2]复旦大学上海医学院肿瘤学系,上海200032 [3]中国科学院上海高等研究院高端医学影像技术研究中心,上海201210

出　　处：《复旦学报（医学版）》2018年第2期158-163,共6页Fudan University Journal of Medical Sciences

基　　金：国家自然科学基金(81301282;81471662);上海市科委科研计划项目(13DZ2250300);上海申康医院发展中心临床辅助科室能力建设项目(SHDC22015030)~~

摘　　要：目的利用乳腺MR影像全自动量化分析法,评估不同月经状态对乳腺纤维腺体组织比(fibrograndular tissue,FGT),背景实质强化容积比(background parenchymal enhancement volume ratio,BPE_V)和程度比(background parenchymal enhancement intensity ratio,BPE_I)的影响。方法从2009年至2012年在复旦大学附属肿瘤医院做乳腺MR检查的14 033名妇女中,随机选出正常乳腺MR影像101例,其中绝经前47例,绝经后54例。绝经前再按月经周期分为:第1周8例,第2至第4周各13例。应用乳腺MR影像全自动量化分析软件测量FGT与增强后早(2 min)、中(4 min)、晚(6 min)3期的BPE_V与BPE_I,并使用Mann-Whitney U检验对绝经前后的FGT,BPE_V和BPE_I进行比较,绝经前各月经周期的比较采用Kruskal-Wallis检验。结果绝经后妇女的FGT,BPE_V与增强中晚期的BPE_I均显著低于绝经前妇女(P<0.05)。BPE_I在绝经前妇女中月经第1周最高,第2周最低(P<0.05)。FGT及BPE_V在月经第1周也最高,但与其他月经周比较差异无统计学意义。结论 FGT、BPE_V和BPE_I在绝经后均显著降低。月经第2周为乳腺MR检查的最佳时间。Objective T o evaluate the influence of menopause status on breast fibrograndular tissue(FG T),background parenchymal enhancement volume ratio(BPEV)and intensity ratio(BPEj)by breast MR image automatic quantitative analysis.Methods From 14 033 consecutive patients who underwent breast MR in our center from 2009 to 2012,we randomly selected 101 normal cases(47 cases of premenopausal and 54 cases of postmenopausal).Premenopausal status was subclassified into four groups(8 cases in the 1st week and 13 cases in the 2nd,3rd and 4th week,respectively)based on the menstrual cycle.We evaluated FGT,BPEV and BPEj at early(2 minutes),medium(4 minutes)and late(6 minutes)enhanced time phases of breast MRI for quantitative assessment.The FGT,BPEV and BPEj in premenopausal and postmenopausal women were compared using the Mann-Whitney U test.Comparison of each menstrual cycle was made using the Kruskal-Wallis test.Results The FG T,BPEV and middle-late BPEj of postmenopausal women were significantly lower than that of premenopausal women(P<C0.05).The maximum BPEi was in the 1st week,the minimum in the 2nd week in premenopausal women(P<C0.05).The FGT and BPEV in the 1st week were the highest among the 4 weeks,but there was no significant difference.Conclusions The FGT,BPEV and BPE!were significantly decreased after menopause.The optimal time of breast MR examination is in the 2nd week of menstrual cycle.

关 键 词：乳腺 纤维腺体组织 背景强化 月经状态 量化分析法 

分 类 号：R816[医药卫生—放射医学]