不同HBV DNA载量患者T细胞亚群及红细胞免疫指标的表达比较  

Comparison on the Expression of T-cell Subsets and Erythrocyte Immune of Patients with Different HBV DNA Loads

作　　者：何亚 唐曙明 李爱敏 HE Ya;TANG Shuming;LI Aimin(Shenzhen City People’s Hospital of Guangdong Province Longhua Branch,Shenzhen 518109,China)

机构地区：[1]广东省深圳市人民医院龙华分院,广东深圳518109

出　　处：《中国医学创新》2018年第1期37-40,共4页Medical Innovation of China

摘　　要：目的:比较不同HBV DNA载量患者T细胞亚群及红细胞免疫指标的表达情况。方法:选取2015年10月-2016年11月期间本院诊治的84例慢性乙肝患者为观察组,同时期的84例健康者为对照组,将两组患者的T细胞亚群(CD3+、CD4+、CD8+及CD4+/CD8+)及相关细胞因子(IL-2、IL-4、IFN-γ及TNF-α)、红细胞免疫指标(FEER、ATER、FEIR及RBC-ICR)水平进行比较,并比较不同HBV DNA载量患者的T细胞亚群及相关细胞因子、红细胞免疫指标表达水平。结果:观察组患者的CD3+、CD4+、CD4+/CD8+、IL-2及FEER、ATER水平均低于对照组(P<0.05),CD8+、IL-4、IFN-γ、TNF-α及FEIR、RBC-ICR水平均高于对照组(P<0.05)。不同HBV DNA载量患者的T细胞亚群及相关细胞因子、红细胞免疫指标表达水平比较差异均有统计学意义(P<0.05)。结论:乙肝患者的T细胞亚群及红细胞免疫指标的表达明显异常,不同HBV DNA载量患者的差异也有显著性,因此上述检测指标对于疾病的诊断价值较高。Objective:To compare the expression situation of T-cell subsets and erythrocyte immune of patients with different HBV DNA loads.Method:84 patients with hepatitis B in our hospital from October 2015 to November 2016 were selected as the observation group,84 healthy persons at the same time were selected as the control group,then the T-cell subsets(CD3+,CD4+,CD8+and CD4+/CD8+),related cytokines(IL-2,IL-4,IFN-γand TNF-α)and erythrocyte immune indexes(FEER,ATER,FEIR and RBC-ICR)of two groups were compared,and the expression levels of T-cell subsets and related cytokines,erythrocyte immune indexes of patients with different HBVDNA loads were compared.Result:The levels of CD3+,CD4+,CD4+/CD8+,IL-2 and FEER,ATER of observation group were all lower than those of control group(P<0.05);the levels of CD8+,IL-4,IFN-γ,TNF-α,FEIR,and RBC-ICR were all higher than those of control group(P<0.05);the expression levels of T-cell subsets and related cytokines,erythrocyte immune indexes of patients with different HBV DNA loads had significant differences(P<0.05).Conclusion:The expression of T-cell subsets and erythrocyte immune of patients with hepatitis B are obviously different,and the differences of patients with different HBV DNA loads are significant,so the detection value of those indexes for the diagnosis of disease are higher.

关 键 词：HBV DNA载量 T细胞亚群 相关细胞因子 红细胞免疫指标 

分 类 号：R512.62[医药卫生—内科学]