超氧化物歧化酶在乙型肝炎和肝细胞癌中的应用价值  

Application value of superoxide dismutase with hepatitis B and hepatocellular carcinoma

作　　者：徐艳秋[1] 刘斌[2] 常媛 赵锐[4] 栾芳[1] XU Yan-qiu;LIU Bin;CHANG Yuan;ZHAO Rui;LUAN Fang(Department of Clinical Laboratory,Provincial Hospital Affiliated to Shandong University,Jinan 250012,China;Department of Biomedical Engineering,Provincial Hospital Affiliated to Shandong University,Jinan 250012,China;Department of Anesthesiology,Provincial Hospital Affiliated to Shandong University,Jinan 250012,China;Department of General Surgery,Qilu Hospital of Shandong University,Jinan 250021,China)

机构地区：[1]山东大学附属省立医院临床医学检验部,山东济南250012 [2]山东大学附属省立医院医学工程部,山东济南250012 [3]山东大学附属省立医院麻醉科,山东济南250012 [4]山东大学齐鲁医院普外科,山东济南250021

出　　处：《中国现代普通外科进展》2017年第11期841-844,共4页Chinese Journal of Current Advances in General Surgery

基　　金：国家自然科学基金青年基金项目(81101484);山东省优秀中青年科学家奖励基金(BS2011SW035)

摘　　要：目的:评估超氧化物歧化酶(SOD)在乙型肝炎和肝细胞癌中的临床应用价值。方法:收集乙型肝炎患者63例、肝细胞癌(HCC)患者101例和正常人58例,酶法检测外周血清中总SOD活性,采用方差分析比较组间SOD活性差异,通过绘制受试者工作特性(ROC)曲线分析SOD对乙型肝炎和HCC的诊断效能。结果:各组间SOD活性由高至低依次是:乙型肝炎组191.500 U/mL,健康对照组(179.766±13.546)U/mL,HCC组150.000 U/mL,两两比较差异有统计学意义(P<0.05)。SOD=187.20 U/mL可作为乙型肝炎诊断临界值,敏感度为65.08%、特异度为75.86%;SOD=166.00 U/mL可作为HCC诊断临界值,敏感度为82.18%、特异度为84.48%;SOD=170.40 U/mL可作为AFP<20 ng/mL的HCC诊断临界值,敏感度为82.76%、特异度为79.31%。结论:SOD活性在健康人、乙型肝炎和HCC患者间存在差异,观察SOD活性变化可了解慢性乙型肝炎是否存在向HCC转化的可能。Objective:To evaluate the activity of superoxide dismutase(SOD)in patients with hepatitis B and Hepatocellular carcinoma.Methods:63 cases of patients with hepatitis B,101 cases of patients with Hepatocellular carcinoma(HCC)and 58 cases of normal control were collected,serum enzyme activity of SOD was detected by enzyme method.Variance analysis were applied to analyze the difference of SOD activity in different groups.Receiver operating characteristic(ROC)were applied to analyze the diagnosis performance of SOD in hepatitis B and HCC patients.Results:SOD activity from high to low in turn was hepatitis B group191.500 U/mL,healthy contol group(179.766±13.546 U/mL)and HCC group 150.000 U/mL,there were significant difference when compareing any two grougs(P<0.05).SOD=187.20 U/mL could be used as diagnosis threshold in hepatitis B patients,the sensitivity was 65.08%and the specificity was 75.86%.SOD=166.00 U/mL can be used as diagnosis threshold in HCC patients,the sensitivity was 82.18%and the specificity was 84.48%.SOD=170.40 U/mL could be used as diagnosis threshold in HCC patients with AFP<20 ng/mL,the sensitivity was 82.76%and the specificity was 79.31%.Conclusion:SOD activity varies in healthy person,hepatitis B and HCC patients.The changes of SOD activity could help us to understand whether there was transformation from hepatitis B to HCC.

关 键 词：超氧化物歧化酶 乙型肝炎 肝细胞癌 

分 类 号：R657.3[医药卫生—外科学]