抗炎产生抗骨质疏松作用的植物  

Herbs protect against osteoporosis through anti-inflammation action

作　　者：杨远超 王颖[2] 方志远[2] 刘学伟[2] 盛彤[2] 王新祥[2] Yang Yuan-chao;Wang Ying;Fang Zhi-yuan;Liu Xue-wei;Sheng Tong;Wang Xin-xiang(School of Basic Medicine,Beijing University of Chinese Medicine,Beijing 100029,China;Dongfang Hospital Affliated to Beijing University of Chinese Medicine,Beijing 100078,China)

机构地区：[1]北京中医药大学基础医学院,北京市100029 [2]北京中医药大学东方医院,北京市100078

出　　处：《中国组织工程研究》2018年第4期638-643,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金(30873290)~~

摘　　要：背景:越来越多的证据表明骨质疏松症的发生和发展与免疫系统功能失常而产生炎症反应直接关联。目的:总结了破骨细胞分化与形成的细胞分子机制,以及几种植物药及其对骨骼发挥保护作用机制,为今后发现更多通过抗炎产生抗骨质疏松作用的植物药,并使其可能成为安全、有效的抗骨质疏松症的食品或药物奠定基础。方法:以"(osteoporosis OR bone loss)AND lipopolysaccharide AND bone resorption;骨质疏松症;核因子κB受体激活剂配基;脂多糖;石斛;马齿苋;蛇葡萄;荆芥"为关键词检索PubM ed数据库和万方数据库,筛选出内容与骨质疏松、炎症及植物药相关的文献,选择在动物实验方面采用脂多糖诱导的小鼠模型的文献。经过筛查、分析,选择4篇较为代表性的文献,对这些植物药的作用机制进行探讨分析。结果与结论:体内实验中,通过计算机显微断层扫描和病理组织切片对小鼠股骨远端海绵骨构造进行分析,石斛、马齿苋、蛇葡萄、荆芥可以抑制脂多糖诱导的炎症性骨质疏松。体外实验中,这4种植物可以抑制破骨细胞分化从而降低骨吸收活性,发挥防治骨质疏松的作用。BACKGROUND:The occurrence and development of osteoporosis are shown to be directly related to the inflammatory response induced by immune dysfunction.OBJECTIVE:To summarize the mechanisms of osteoclast differentiation and formation at cellular and molecular levels,as well as the underlying mechanisms of several kinds of medical herbs against osteoporosis,thus paving ways for finding more effective and safe herbs for anti-osteoporosis.METHODS:PubMed database was retrieved using the English keywords of(osteoporosis OR bone loss)AND lipopolysaccharide AND bone resorption”,and WanFang database was searched with the Chinese keywords of“osteoarthritis,receptor activator of nuclear factor-κB ligand,lipopolysaccharide,Dendrobium moniliforme,Portulaca oleracea,Ampelopsis sinica,Schizonepeta”.The literatures addressing osteoporosis,inflammation and herbal medicine were screened,and those using lipopolysaccharide-induced mouse models were included.Finally,four eligible literatures were enrolled for review.RESULTS AND CONCLUSION:In vivo experiments,CT images and pathological sections of the cancellous bone in the mouse distal femur show that Dendrobium moniliforme,Purslane oleracea,Ampelopsis sinica,and Schizonepeta exert inhibitory effects on lipopolysaccharide-induced osteoporosis.In vitro experiments reveal that these four kinds of herbs fight against osteoporosis by inhibiting osteoclast differentiation and further reducing bone resorption.

关 键 词：骨质疏松症 炎症 核因子κB受体激活剂配基 脂多糖 石斛 马齿苋 蛇葡萄 荆芥 组织构建 

分 类 号：R318[医药卫生—生物医学工程]