高尿酸血症患者血尿酸与血清HGPRT、VitC水平的相关性  

Relationship between serum uric acid and levels of HGPRT and VitC in serum in hyperuricemia patients

作　　者：刘景芳 邵春海 张家瑛 白雪林 张敏[3] 潘美珍 LIU Jing-fang;SHAO Chun-hai;ZHANG Jia-ying;BAI Xue-lin;ZHANG Min;PAN Mei-zhen(Department of Clinical Nutrition,Huashan Hospital,Fudan University,Shanghai 200040,China;Community Health Service Center of Xinjing Town in Changning District,Shanghai 200335,China;Department of Nutrition,the People’s Hospital of Shanghai Pudong District,Shanghai 201200,China;Department of Nutrition,Pudong Hospital of Shanghai,Shanghai 201300,China)

机构地区：[1]复旦大学附属华山医院临床营养科,上海200040 [2]上海市长宁区新泾镇社区卫生服务中心,上海200335 [3]上海市浦东新区人民医院营养科,上海201200 [4]上海市浦东医院营养科,上海201300

出　　处：《中国临床医学》2018年第1期22-26,共5页Chinese Journal of Clinical Medicine

基　　金：上海市卫生和计划生育委员会科研课题面上项目(20134256)~~

摘　　要：目的:探讨高尿酸血症(hyperuricemia,HUA)的危险因素,为有效控制血尿酸(serum uric acid,SUA)提供依据。方法:2015年1月至12月每3个月从上海市4家医院的体检人群中筛选一批SUA≥420μmol/L的受试者,共筛选出受试者144例。入组时,对所有受试者复测SUA浓度,将SUA异常者(SUA≥420μmol/L)94例作为HUA组,SUA正常者(SUA<420μmol/L)50例作为SUA正常组。对所有受试者进行问卷调查、人体参数测量及血生化指标检测。结果:男性SUA浓度显著高于女性(P<0.001);饮酒者SUA浓度显著高于不饮酒者(P=0.01);经常运动者SUA浓度明显低于不经常运动者(P=0.004)。收缩压与SUA浓度正相关(r=0.166,P=0.047),谷类摄入量(r=-0.215,P=0.010)、血清维生素C(vitamin C,VitC)浓度(r=-0.294,P<0.001)和血清次黄嘌呤-鸟嘌呤磷酸核糖转移酶(hypoxanthine-guanine phosphoribosyl transferase,HGPRT)活性(r=-0.236,P=0.004)与SUA浓度负相关。SUA线性回归方程是,SUA=452.87(μmol/L)+1.598×收缩压(mmHg)-0.409×谷类摄入量(g)-2.231×血清VitC(mmol/L)-0.162×HGPRT(mmol/L)。结论:谷类摄入、血清VitC和HGPRT是HUA的保护因素,收缩压是HUA的危险因素;建议HUA者(尤其是男性)应在均衡营养的基础上保证谷类摄入,增加VitC摄入,戒酒,坚持运动,并积极控制收缩压。Objective:To investigate the risk factors of hyperuricemia(HUA),so as to provide the basis for effective control of serum uric acid(SUA).Methods:Totally 144 subjects with SUA≥420μmol/L were recruited from physical examination population from January to December 2015 in four hospitals of Shanghai.At the time of enrollment,all the subjects were retested for SUA.Among them,94 subjects with SUA≥420μmol/L were taken as HUA group,and 50 subjects with SUA<420μmol/L as SUA normal group.All the subjects underwent questionnaires,anthropometric measurements and biochemical tests.Results:The SUA level was significantly higher in male than that in female(P<0.001),higher in drinkers than that in non-drinkers(P=0.01),and lower in those taking exercise than that in those without exercise(P=0.004).SUA level was positively correlated with systolic blood pressure(r=0.166,P=0.047),and negatively correlated with cereal intake(r=-0.215,P=0.01),serum vitamin C(VitC)concentration(r=-0.294,P<0.001)and serum hypoxanthine-guanine phosphoribosyl transferase(HGPRT)activity(r=-0.236,P=0.004).The linear regression equation of SUA was as follows:452.870(μmol/L)+1.598×systolic blood pressure(mmHg)-0.409×cereal intake(g)-2.231×serum VitC(mmol/L)-0.162×HGPRT(mmol/L).Conclusions:Cereal intake,serum VitC concentration and HGPRT activity are the protective factors of HUA,while systolic blood pressure is a risk factor.It is suggested that the people with HUA(especially men)should take optimal dietary,including adequate cereals,vegetables and fruits rich in VitC or oral supplements of VitC on the basis of balanced nutrition.It is also proposed that they should abstain from alcohol,take regular exercise and control systolic blood pressure for better control of SUA.

关 键 词：高尿酸血症 血尿酸 维生素C 次黄嘌呤-鸟嘌呤磷酸核糖转移酶 

分 类 号：R589.9[医药卫生—内分泌]