降脂抗凝降压药物联合银杏胶囊对颈动脉硬化患者内皮损伤、斑块稳定性的影响  

Effects of lipid-lowing anticoagulant antihypertensive drugs combined with ginkgo capsule on endothelial injury and plaque stability in patients with carotid atherosclerosis

作　　者：邹时念 王祖斌[2] ZOU Shi nian;WANG Zu bin(Department of Rehabilitation,Songzi People's Hospital in Hubei Province,Songzi,Hubei Province,434200,China;Department of Pharmacy,Songzi People's Hospital in Hubei Province,Songzi,Hubei Province,434200,China)

机构地区：[1]湖北省松滋市人民医院康复科,湖北松滋434200 [2]湖北省松滋市人民医院药剂科,湖北松滋434200

出　　处：《海南医学院学报》2018年第3期297-300,共4页Journal of Hainan Medical University

基　　金：湖北省科技计划项目(2011CJ3076)~~

摘　　要：目的:探讨降脂抗凝降压药物联合银杏胶囊对颈动脉硬化患者内皮损伤、斑块稳定性的影响。方法:收集在本院康复科接受治疗的颈动脉硬化患者114例,经随机数表法分为对照组、银杏胶囊组各57例。对照组患者接受常规降脂抗凝降压药物治疗,银杏胶囊组患者在降脂抗凝降压治疗基础上加入银杏胶囊治疗。对比两组患者治疗前后内皮损伤、斑块稳定性的差异。结果:治疗前,两组血清中内皮功能指标、斑块稳定性相关指标含量的差异无统计学意义。治疗1月后、治疗6月后,银杏胶囊组血清中内皮损伤指标sVCAM-1、vWF、ET-1的含量低于对照组相应时间点,NO、6-Reto-PGF1α的含量高于对照组相应时间点;血清中斑块稳定性相关指标LEP、RETN、Hcy、PTX3、Lp-PLA2的含量低于对照组相应时间点,APN的含量高于对照组相应时间点。结论:颈动脉硬化患者接受降脂抗凝降压药物联合银杏胶囊治疗,可有效保护血管内皮功能并稳定粥样斑块。Objective:To investigate the effects of lipid lowing anticoagulant antihypertensive drugs combined with ginkgo capsule on endothelial injury and plaque stability in patients with carotid atherosclerosis.Methods:114 patients with carotid atherosclerosis who were treated in Songzi People's Hospital between April 2016 and January 2017 were collected and divided into control group(n=57)and ginkgo capsule group(n=57)by random number table.Control group received conventional lipid lowing anticoagulant antihypertensive drug therapy and ginkgo capsule group received lipid lowing anticoagulant antihypertensive drugs combined with ginkgo capsule therapy.The differences in endothelial injury and plaque stability were compared between the two groups before and after treatment.Results:There was no statistically significant difference in serum levels of endothelial function indexes and plaque stability related indexes between the two groups before treatment.After 1 month of treatment and after 6 months of treatment,serum endothelial injury indexes sVCAM 1,vWF and ET 1 levels of ginkgo capsule group were lower than those of control group at corresponding points in time whereas NO and 6 Reto PGF1αlevels were higher than those of control group at corresponding points in time;serum plaque stability related indexes LEP,RETN,Hcy,PTX3 and Lp PLA2 levels were lower than those of control group at corresponding points in time whereas APN levels were higher than those of control group at corresponding points in time.Conclusion:Lipid lowing anticoagulant antihypertensive drugs combined with ginkgo capsule therapy can effectively protect the vascular endothelial function and stabilize the atherosclerotic plaque in patients with carotid atherosclerosis.

关 键 词：颈动脉硬化 银杏胶囊 内皮损伤 斑块稳定性 

分 类 号：R543.12[医药卫生—心血管疾病]