匹多莫德联合粉尘螨滴剂对变应性鼻炎伴哮喘患儿免疫炎症反应的影响  

Effects of pidotimod combined with dermatophagoides farinae drops on the immune inflammatory response in children with allergic rhinitis complicated by asthma

作　　者：罗劲松[1,2] 杨小平 马春花[2] 张小玲[2] 马俐雅[2] 姚金梅 LUO Jin song;YANG Xiao ping;MA Chun hua;ZHANG Xiao ling;MA Li ya;YAO Jin mei(Department of Pediatrics,People's Hospital of Wuhan University,430060;Department of Pediatrics,the Fifth Division Hospital of Xinjiang Production and Construction Corps,833400)

机构地区：[1]武汉大学人民医院儿科,湖北武汉430060 [2]新疆生产建设兵团第五师医院儿科,新疆833400

出　　处：《海南医学院学报》2018年第3期335-337,341,共4页Journal of Hainan Medical University

基　　金：国家自然科学基金(81471465)~~

摘　　要：目的:探讨匹多莫德联合粉尘螨滴剂对变应性鼻炎伴哮喘患儿免疫炎症反应的影响。方法:选取在本院接受治疗的变异性鼻炎合并哮喘患儿142例,随机分为对照组、研究组各71例。对照组接受粉尘螨滴剂治疗,研究组患儿接受匹多莫德联合粉尘螨滴剂治疗。对比两组治疗前、治疗1月后血清中免疫球蛋白及炎症因子含量的差异。结果:治疗前,两组血清中免疫球蛋白、Th1/Th2细胞因子、Th17/Treg细胞因子含量的差异无统计学意义。治疗1月后,血清中sIgE的含量低于对照组,sIgG4的含量高于对照组;血清中Th1细胞因子IFN-γ、IL-2的含量高于对照组,Th2细胞因子IL-4、IL-5的含量低于对照组;血清中Th17细胞因子IL-17的含量低于对照组,Treg细胞因子IL-10的含量高于对照组。结论:变应性鼻炎伴哮喘患儿接受匹多莫德联合粉尘螨滴剂治疗,可有效优化患儿的免疫功能并抑制全身炎症反应。Objective:To investigate the effects of pidotimod combined with dermatophagoides farinae drops on the immune inflammatory response of children with allergic rhinitis complicated by asthma.Methods:142 children with allergic rhinitis complicated by asthma who were treated in this hospital between March 2014 and January 2017 were selected and divided into the control group(n=71)and study group(n=71)by random number table method.Control group were treated with dermatophagoides farinae drops,and study group received pidotimod combined with dermatophagoides farinae drops therapy.The differences in serum contents of immunoglobulin and inflammatory cytokines were compared between two groups of children before treatment and after 1 month of treatment.Results:There was no statistically significant difference in serum contents of immunoglobulin,Th1/Th2 cytokines and Th17/Treg cytokines between the two groups before treatment.After 1 month of treatment,serum sIgE content was lower than that of control group whereas sIgG4 content was higher than that of control group;serum Th1 cytokines IFNγand IL 2 contents were higher than those of control group whereas Th2 cytokines IL 4 and IL 5 contents were lower than those of control group;serum Th17 cytokine il 17 content was lower than that of control group whereas Treg cytokine IL 10 content was higher than that of control group.Conclusion:Pidotimod combined with dermatophagoides farinae drops can effectively optimize the immune function and suppress the systemic inflammatory response in children with allergic rhinitis complicated by asthma.

关 键 词：变应性鼻炎 哮喘 匹多莫德 粉尘螨滴剂 免疫反应 炎症反应 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]