几种凝血/纤溶标志物在部分血栓性疾病中的应用  

Application of Several Coagulation/Fibrinolysis Markers in Partial Thrombotic Diseases

作　　者：郭晓倩[1] 任玮[1] 李艳[1] GUO Xiao-qian;REN Wei;LI Yan(Department of Clinical Laboratory,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院检验科,武汉430060

出　　处：《微循环学杂志》2018年第1期63-66,共4页Chinese Journal of Microcirculation

基　　金：国家重点临床专科建设项目(财社[2010]305号)

摘　　要：机体凝血增强、纤溶降低,可能预警血栓形成。相关标志物凝血酶-抗凝血酶复合物(TAT)、纤溶酶-α2纤溶酶抑制剂复合物(PIC)、血栓调节蛋白(TM)、组织纤溶酶原激活物-纤溶酶原激活物抑制剂-1复合物(tPAI-C)、纤维蛋白(原)降解产物(FDP)和D-二聚体(DD)水平异常成为临床上分析血栓性病变的重要参考指标,并在深静脉血栓、心血管疾病、弥散性血管内凝血(DIC)等的应用中获益。这些指标能反映血管内皮受损、血液高凝、纤溶状态,相较于常规指标:凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)等的变化,出现更早、更灵敏,因而对血栓形成的警示更及时,遗漏更少。When coagulation is increased and fibrinolysis decreased,it prones to thrombosis.Relevant markers such as thrombin-antithrombin complex(TAT),plasmin inhibitor-plasmin complex(PIC),thrombomodulin(TM),tissue plasminogen activator-plasminogen activator inhibitor-1 complex(t-PAI-C),fibrin(-ogen)degradation products(FDP)and D-Dimer(DD),are important reference markers for clinically thrombotic disorders,which suggest vascular endothelial damage,hypercoagulable and fibrinolytic system activation.It benefits in applications such as deep vein thrombosis,cardiovascular disease,DIC and so on.Compared with traditional coagulation indicators,prothrombin time(PT),activated partial thromboplastin time(APTT),thrombin time(TT),Fibrinogen(FIB),these markers are more sensitivity to screen and diagnose the hemorrhagic disease and thrombosis at its early stage.And thus,it is more alert to the thrombotic lesion.

关 键 词：凝血/纤溶标志物 深静脉血栓 心血管疾病 弥散性血管内凝血 

分 类 号：R446.112[医药卫生—诊断学]