盐酸氨溴索辅助治疗对加重期慢性阻塞性肺疾病患者疗效及生存质量的影响  

Effects of Ambroxol Hydrochloride Assisted Therapy on the Clinical Symptoms,Pulmonary Ventilation Function and Quality of Life of Patients with Exacerbation of Chronic Obstructive Pulmonary Disease

作　　者：朱齐琦 李军[1] 王琴[1] ZHU Qiqi;LI Jun;WANG Qin(Jiujiang First People’s Hospital,Jiujiang 332000,China)

机构地区：[1]江西省九江市第一人民医院,江西九江332000

出　　处：《中国医学创新》2018年第5期116-119,共4页Medical Innovation of China

摘　　要：目的:观察盐酸氨溴索辅助治疗对加重期慢性阻塞性肺疾病(COPD)患者的临床症状、肺部通气功能以及生存质量的影响。方法:选取2016年2月-2017年3月本院收治的加重期COPD患者94例,按照随机数字表法分为对照组和观察组,各47例。对照组给予常规治疗,观察组在对照组基础上使用盐酸氨溴索辅助治疗,均以7 d为一疗程。比较两组治疗后的临床症状缓解时间和生活质量评分、治疗前后的肺部通气功能、疗效。结果:治疗后,观察组咳嗽、肺部湿啰音、胸闷气短的缓解时间均短于对照组,FVC、FEV_1、FEV_1%均高于对照组,各项生活质量评分均高于对照组,比较差异均有统计学意义(P<0.05);观察组总有效率为95.7%,高于对照组的72.3%,比较差异有统计学意义(χ~2=0.598,P=0.002)。结论:加重期COPD患者使用盐酸氨溴索辅助治疗,能够缓解患者临床症状,提升患者肺部通气功能,同时增强治疗效率。Objective:To observe the effects of Ambroxol Hydrochloride assisted therapy on the clinical symptoms,pulmonary ventilation function and quality of life of patients with exacerbation of chronic obstructive pulmonary disease(COPD).Method:A total of 94 patients with exacerbation of COPD treated in our hospital from February 2016 to March 2017 were selected.According to the random number table method,they were divided into control group and observation group,47 cases in each group.The control group was given routine treatment,and observation group was treated with Ambroxol Hydrochloride assisted therapy on the basis of control group,7 d as a course of treatment.The remission time of clinical symptoms and quality of life after treatment,pulmonary ventilation function before and after treatment,curative effect were compared between two groups.Result:After treatment,the remission time of cough,lung wet rales,chest tightness and shortness of breath in observation group were shorter than those of control group,FVC,FEV1,FEV1%were higher than those of control group,the each score of quality of life were higher than those of control group,the differences were statistically significant(P<0.05).The total efficiency of observation group was 95.7%,which was higher than 72.3%of control group,the difference was statistically significant(χ2=0.598,P=0.002).Conclusion:The use of Ambroxol Hydrochloride assisted therapy in patients with exacerbation of COPD can relieve the clinical symptoms,improve the pulmonary ventilation function and enhance the efficiency of the treatment.

关 键 词：盐酸氨溴索 慢性阻塞性肺疾病 肺部功能 

分 类 号：R563.9[医药卫生—呼吸系统]