原发性肝癌患者症状体征与血清AFP关系的探讨  

Relationship between symptoms,signs and serum levels of Alpha-fetoprotein in patients with primary hepatocellular carcinoma

作　　者：周晓萍[1] 张玲[2] 吴君荣[3] ZHOU Xiao-ping;ZHANG Ling;WU Jun-rong(Department of Laboratory Medicine,the First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530022,China)

机构地区：[1]广西中医药大学第一附属医院检验科,南宁530022 [2]广西中医药大学附属瑞康医院肝病科,南宁530001 [3]广西医科大学附属肿瘤医院检验科,南宁530021

出　　处：《中国临床新医学》2018年第2期128-133,共6页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：广西高校中青年教师基础能力提升项目(编号:2017KY0127)

摘　　要：目的分层研究血清AFP水平与原发性肝癌(PHC)患者各临床症状和体征的相关性。方法采用SPSS19.0软件统计分析PHC患者不同层次血清AFP水平中的各临床症状和体征。结果本研究共纳入1 030例PHC患者,Logistic回归分析发现,年龄、腹痛、腹胀、影像学检查为块状型、病理检查为肝细胞型及胆管细胞型对血清AFP水平有明显影响。通过线性趋势分析发现肝硬化、腹痛、腹胀、腹水、肝大、影像学检查为块状型、大三阳及小三阳百分率随AFP水平的升高而呈现增加趋势,而影像学检查为结节型、病理检查为肝细胞型和胆管细胞型阳性百分率随AFP水平的升高而呈现下降趋势。结论临床上应动态监测PHC患者血清AFP水平,并密切观察患者症状和体征的变化,更好地提高PHC患者的治疗效果。ObjectiveTo explore the relationship between symptoms,signs and different levels of Alpha fetoprotein(AFP)in the patients with primary hepatocellular carcinoma(PHC).MethodsSPSS19.0 was used to statistically analyze the symptoms and signs of PHC patients with different levels of AFP.ResultsA total of 1 030 PHC patients were included in this study.The results of the Logistic regression analysis showed that the following factors have a significant effect on AFP levels:age,abdominal pain,bloating,block type,type of liver cells and bile duct cell type.The results from the linear trend analysis indicated that the percentage of positive cirrhosis,abdominal pain,bloating,ascites,hepatomegaly,massive,HBsAg,HBeAg and Anti HBc positive and HBsAg,Anti HBe and Anti HBc positive increased with elevated AFP,while the percentage of positive nodular,type of liver cells and bile duct cell type decreased with elevated AFP.ConclusionThe serum levels of AFP should be dynamically detected and the clinical symptoms and signs should be observed carefully to make the PHC patients treated more timely and effectively.

关 键 词：甲胎蛋白 原发性肝癌 症状 体征 

分 类 号：R543.5[医药卫生—心血管疾病]