烟曲霉生物膜研究进展  

Research progress of Aspergillus fumigatus biofilms

作　　者：童建波 曾荣[1] 李岷[1] TONG Jian-bo;ZENG Rong;LI Min(Institute of Dermatology,Chinese Academy of Medical Sciences and Peking Union Medical College;Jiangsu Key Laboratory of Molecular Biology for Skin Diseases,Nanjing 210042,China)

机构地区：[1]中国医学科学院北京协和医学院皮肤病研究所,江苏省皮肤性病学分子生物学重点实验室,南京210042

出　　处：《中国真菌学杂志》2018年第1期61-64,共4页Chinese Journal of Mycology

基　　金：国家自然科学基金(81502739);江苏省自然科学基金(BK20150068)

摘　　要：近年来侵袭性曲霉病的发病率逐年上升,因其极高的致死率而引起了临床上广泛的关注。研究发现烟曲霉的生物膜形态是其重要致病形态。生物膜一旦形成其对多种抗真菌药物的耐药性、致病性将增加。这可能是导致临床高死亡率最直接的原因。该文主要从烟曲霉生物膜形成特点、致病性及其耐药机制和目前主要的生物膜研究方法等方面进行综述。The frequency of invasive aspergillosis had dramatically increased year after year andthe high mortality rate had caused extensive concern of clinicians.The biofilm morphology which had been wildly recognized could enhanced pathogenicity to host and increase resistance to antimicrobial agents.Therefore,Biofilms might play an important role in causing high mortality rates.This review discussed the characteristics of Aspergillus fumigatus biofilm formation,biofilm detection methods and its mechanisms of drug resistance.

关 键 词：烟曲霉 生物膜 检测方法 耐药机制 

分 类 号：R379.6[医药卫生—病原生物学]