染料木素对运动疲劳大鼠肝功能和脂代谢的影响  

Effect of Genistein on Liver Function and Lipid Metabolism in Rats with Exercise-induced Fatigue

作　　者：曹性玲[1] 麻海娟 黄钘 滕袓宏 吴丽珍[1] 曾丽梅[1] 黄志华[1] 李良东[1] 

机构地区：[1]赣南医学院基础医学院,江西赣州341000 [2]赣南医学院,江西赣州341000

出　　处：《赣南医学院学报》2018年第1期1-4,共4页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：国家自然科学基金项目(NO.81760654);江西省教育厅科技重点项目(NO.GJJ160968)

摘　　要：目的:探讨染料木素(Genistein,Gen)对运动疲劳大鼠肝功能和血脂代谢的影响。方法:雄性SD大鼠,随机分为正常对照组、运动疲劳模型组、低剂量(0.1μM·kg^(-1))Gen组和高剂量(0.3μM·kg^(-1))Gen组。强迫游泳法制备运动性疲劳模型,皮下注射方法给予不同剂量Gen或溶剂处理,连续14 d。末次运动后于腹腔静脉取血,检测各组动物血清中肝功能和血脂(ALT、AST、TC、TG、HDL、LDL、VLDL和HBDH)含量的变化。结果:各组间ALT和AST含量无差异。与正常组相比,运动疲劳会导致TC、TG含量明显降低,同时可降低血浆中的LDL、VLDL及HDL水平,抑制HBDH的活性。而Gen则可显著上调上述指标。结论:Gen可缓解运动疲劳所导致的肝功能和血脂的代谢异常,起抗运动疲劳的作用。Objective:To observe the effect of genistein on liver function and lipid metabolism in the exercise-induced fatigue rats.Methods:Male SD rats were randomly divided into normal control group,exercise-induced fatigue model groups,low dose genistein-group and high dose genistein-group.The exercise-induced fatigue model was made by forced exhaustive swimming with subcutaneous injection of different doses genistein or solvent for 14 days continuously.After the last swimming,the blood samples were taken from the abdominal vein to detect the changes of liver function in serum and the contents of ALT,AST,TC,TG,HDL,LDL,VLDL and HBDH in serum lipids in each group.Results:There was no difference in ALT and AST content among groups.When compared with the normal control group,exercise-induced fatigue significantly decreased the content of TC and TG,down-regulated the level of LDL,VLDL and HDL,and inhibited the activity of HBDH.However,Genistein had the opposite effect.Conclusion:Genistein has the effect of anti-exercise fatigue,which can alleviate the abnormal metabolism of liver function and blood lipids caused by exercise fatigue.

关 键 词：染料木素 运动疲劳 肝功能 脂代谢 

分 类 号：R285.5[医药卫生—中药学]