水陆二仙丹加减方治疗早期糖尿病肾病临床观察  

Water and Land Dendroxine Treatment Clinical Observation of Early Diabetic Nephropathy

作　　者：陈龙[1] CHEN Long(Hanchuan People’s Hospital of Hubei Province,Hanchuan 431600,China)

机构地区：[1]湖北省汉川市人民医院,湖北汉川431600

出　　处：《中国医学创新》2017年第34期111-114,共4页Medical Innovation of China

摘　　要：目的:观察水陆二仙丹加减方治疗早期糖尿病肾病的临床疗效。方法:选择本院2013年3月-2016年3月收治的诊断为糖尿病肾病的患者,进行临床分期,中医症候分析,选取分期为Ⅲ期,中医辨证为脾肾气阴两虚兼血症患者62例,采用随机数字表法分为两组,每组各31例。对照组予以糖尿病低蛋白饮食,常规控制血糖、血脂,血压高者给予依拉普利5 mg qd,必要时加用钙拮抗剂,使血压控制在140/90 mm Hg以下;观察组在对照组的基础上加用导师经验方汤剂200 mL bid治疗,所有治疗持续12周。观察两组的MAU、BUN、Scr、水平及中医症候积分。结果:两组治疗后的尿微量白蛋白定量分析较治疗前明显减低(P<0.05),且试验组与对照组相比差异有统计学意义(P<0.05)。观察组治疗后总有效率90.32%,对照组治疗后总有效率51.61%,两组比较差异有统计学意义(P<0.01)。结论:中西结合治疗可以明显改善糖尿病肾病Ⅲ期患者的临床症状,能显著降低Ⅲ期糖尿病肾病患者的尿微量白蛋白。Objective:To observe the curative effect of water and land dendroxine in treating early diabetic nephropathy.Method:62 patients with early diabetic nephropathy were selected from March 2013 to March 2016.They were randomly divided into two groups according to TCM syndrome differentiation,31 cases in each group.The control group was given diabetes low protein diet,routine control of blood sugar,and blood lipids,the high blood pressure patients were given Lopril 5 mg qd,if necessary,plus calcium antagonists,so that blood pressure control in 140/90 mm Hg below.The observation group on the basis of the control group plus mentor experience decoction 200 mL bid treatment.All treatment lasted 12 weeks,the levels of MAU,BUN,Scr,and TCM syndrome points of two groups were observed.Result:The amount of microalbuminuria in the two groups was significantly lower than that before treatment(P<0.05),and the difference between the observation group and the control group was significant(P<0.05).The total effective rate was 90.32%in the observation group and 51.61%in the control group,the difference was statistically significant(P<0.01).Conclusion:Chinese and western combination therapy can significantly improve the clinical symptoms of early diabetic nephropathy,can significantly reduce the early diabetic nephropathy in patients with microalbuminuria.

关 键 词：早期糖尿病肾病 水陆二仙丹 加减方 临床观察 

分 类 号：R587.2[医药卫生—内分泌]