2-氯-4-苯基喹唑啉的合成  

Synthesis of 2-Chloro-4-phenylquinazoline

作　　者：胡昆[1] 张美菊 吴冬冬[1] 赵世凡 谢宇轩 任杰[1] HU Kun;ZHANG Mei-ju;WU Dong-dong;ZHAO Shi-fan;XIE Yu-xuan;REN Jie(School of Pharmaceutical Engineering&Life Science,Changzhou University,Changzhou 213164,China)

机构地区：[1]常州大学制药与生命科学学院,江苏常州213164

出　　处：《合成化学》2018年第3期203-205,共3页Chinese Journal of Synthetic Chemistry

摘　　要：以邻苯甲酰苯甲酸为原料,依次经氯代、酰胺化、Hofmann重排、成环及氯化共5步反应合成了2-氯-4-苯基喹唑啉,总收率20.8%,其结构经~1H NMR和^(13)C NMR确证。2-Chloro-4-phenylquinazoline with the total yield of 20.8%was synthesized by five-steps reaction of chloridization,amidation,Hofmann rearrangement,cyclization and chlorination,using 2-benzoylbenzoic acid as the starting material.The structure was confirmed by 1 H NMR and 13 C NMR.

关 键 词：邻苯甲酰苯甲酸 2-氯-4-苯基喹唑啉 Hofmann重排 成环反应 合成 

分 类 号：O626[理学—有机化学]