生物催化C—H键不对称羟基化反应的研究进展  

Research Progress on the Biocatalytic Asymmetric Hydroxylation of C—H Bonds

作　　者：何青 万南微 陈永正[1,2] HE Qing;WAN Nan-wei;CHEN Yong-zheng(School of Pharmacy,Zunyi Medical University,Zunyi 563000,China;Green Pharmaceuticals Engineering Research Center of Guizhou Province,Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]遵义医学院药学院,贵州遵义563000 [2]遵义医学院贵州省绿色制药工程研究中心,贵州遵义563000

出　　处：《合成化学》2018年第3期214-228,共15页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(21162047;21562054;21262051)

摘　　要：C—H键的不对称羟基化反应是有机合成领域的研究热点和难点之一。生物催化的不对称羟基化反应具有较好的区域选择性和立体选择性,可作为化学催化C—H键不对称羟基化方法的有力补充,而目前关于生物催化的C—H键不对称羟基化反应的评论文章鲜有报道。本文结合本课题组的研究基础,根据底物类型,综述了生物催化链烷烃、环烷烃、芳香烷烃、烯烃、杂环化合物和天然化合物的不对称羟基化反应的进展,参考文献44篇。Asymmetric hydroxylation of C-H bond is a hot and difficult point in organic synthesis.Biocatalytic asymmetric hydroxylation reactions usually exhibit excellent regio-and stereoseletivity,which make them become a powerful complement of chemical catalyzed hydroxylation.And the paper reviewed on biocatalytic asymmetric hydroxylation reactions is very rare to the present time.Based on our group’s research foundation on this area,this review sums up biocatalytic asymmetric hydroxylation reactions toward linear alkane,cyclic alkane,aromatic alkane,olefin,heterocyclic compounds and natural compounds with 44 references.

关 键 词：生物催化 不对称羟基化 P450单加氧酶 过氧化物酶 综述 

分 类 号：O621.3[理学—有机化学]