抗菌肽BSN-37的生物信息学分析  

Bioinformatics analysis of antimicrobial peptide BSN-37

作　　者：杭柏林[1] 张炜 李杰 徐军[1] 徐彦召[1] 张慧辉[1] 胡建和[1] HANG Bolin;ZHANG Wei;LI Jie;XU Jun;XU Yanzhao;ZHANG Huihui;HU Jianhe(School of Animal Science and Veterinary Medicine,Henan Institute of Science and Technology,Xinxiang 453003,China;Xinxiang Agriculture and Animal Husbandry Bureau,Xinxiang 453003,China)

机构地区：[1]河南科技学院动物科技学院,河南新乡453003 [2]新乡市农牧局,河南新乡453003

出　　处：《河南科技学院学报（自然科学版）》2018年第1期34-38,共5页Journal of Henan Institute of Science and Technology(Natural Science Edition)

基　　金：河南省高校科技创新团队支持计划(15IRTSTHN);河南科技学院高层次人才启动项目(2014020);河南科技学院2015年大学生"百农英才"创新项目(BNYC2015-2-09)

摘　　要：为研究抗菌肽BSN-37的生物学功能,利用在线软件分析了抗菌肽BSN-37的生物信息学特性.结果表明:抗菌肽BSN-37有8个正电荷氨基酸,为阳离子型亲水性抗菌肽,等电点为12.48,富含脯氨酸和精氨酸,主要由β转角和无规则卷曲构成,没有信号肽、跨膜区和磷酸化位点,有多个蛋白酶切位点,存在抗原表位.根据分析结果推测抗菌肽BSN-37除膜作用机制外还有其他独特的抗菌机制.To research the biological function of antimicrobial peptide BSN-37,tools on line were utilized to analyze some informatics feature of BSN-37.The results showed that antimicrobial peptide BSN-37,which have eight positive charge amino acids and are rich with proline and arginine,are cationic and hydrophilic antimicrobial peptide,and the isoelectric point are 12.48.BSN-37 are mainly consist of turn and coil.BSN-37 have no signal peptide,transmembrane region and phosphorylation sites.BSN-37 have several enzyme digestion sites and several epitopes.These findings suggested that antimicrobial peptides BSN-37 could kill bacteria through interaction with cell membrane and other specific mechanism.

关 键 词：抗菌肽 生物信息学 预测 BSN-37 氨基酸序列 

分 类 号：Q517[生物学—生物化学]