重症支原体肺炎患儿血小板参数测定的临床意义  

Clinical significance of platelet parameters in children with severe mycoplasma pneumonia

作　　者：杨雪[1] 林荣军[1] 金蓉[1] 路玲[1] 管仁政[1] 王仙金 Yang Xue;Lin Rongjun;Jin Rong;Lu Ling;Guan Renzheng;Wang Xianjin(Department of Pediatric,the Affiliated Hospital of Qingdao University,Qingdao 266000,China)

机构地区：[1]青岛大学附属医院儿科,266000

出　　处：《中华诊断学电子杂志》2018年第1期37-40,共4页Chinese Journal of Diagnostics(Electronic Edition)

摘　　要：目的探讨血小板参数测定对重症支原体肺炎(SMPP)患儿诊治的临床意义。方法回顾性收集2015年9月至2017年2月于青岛大学附属医院儿科住院治疗的支原体肺炎患儿,共180例,依据临床表现分为:重症组(SMPP组)90例,轻症组(MPP组)90例,选取本院同期小儿外科住院治疗的腹股沟斜疝患儿90例作为对照组,采用病例-对照法进行研究。依据支原体肺炎患儿的发病时间、症状、体征、影像学表现,划分急性期与恢复期,每组各90例。3组患儿分别采集外周静脉血行血小板参数测定,包括血小板计数(PLT)、血小板分布宽度(PDW)、血小板体积(MPV)、血小板压积(PCT)、大血小板比率(P-LCR),采用t检验或F检验比较各组水平差异。结果 SMPP组患儿,急性期与恢复期比较,各项血小板参数均差异有统计学意义[PLT(242.06±62.44)×10~9/L、PDW(10.74±2.34)%、MPV(9.58±0.85)f L、PCT(0.25±0.09)%、P-LCR(22.21±5.98)%和PLT(405.11±101.00)×10~9/L、PDW(9.87±1.67)%、MPV(9.22±0.67)f L、PCT(0.37±0.09)%、P-LCR(20.07±3.23)%;t=-13.02,2.87,3.14,-8.65,2.30;均P<0.05]。急性期,与对照组比较,SMPP组PLT、PCT水平显著降低,MPP组PLT、PCT水平显著升高,差异有统计学意义[SMPP组、MPP组、对照组分别为PLT(242.06±62.44)×10~9/L、(333.28±92.60)×10~9/L、(287.36±36.29)×10~9/L和PCT(0.25±0.09)%、(0.32±0.12)%、(0.28±0.05)%;F=40.67,18.52;均P<0.05];恢复期,与对照组比较,SMPP组及MPP组PLT、PCT水平均显著升高,差异有统计学意义[SMPP组、MPP组、对照组分别为PLT(405.11±101.00)×10~9/L、(328.78±76.30)×10~9/L、(287.36±36.29)×10~9/L和PCT(0.37±0.09)%、(0.32±0.07)%、(0.28±0.05)%;F=55.56,39.76;均P<0.05]。结论关注血小板参数变化,尤其是PLT、PCT水平的变化,可早期诊断SMPP并判断其病情变化。Objective To investigate the clinical significance of platelet parameters in the diagnose the treatment of children with severe mycoplasma pneumonia(SMPP).Methods One hundred and eighty patients with mycoplasma pneumonia(MPP)admitted to pediatric department of the Affiliated Hospital of Qingdao University from September 2015 to February 2017 were selcected for a retrospective study.Among them,90 cases in severe group(SMPP group)and 90 cases in mild group(MPP group),and 90 cases with inguinal hernia as a control group during the same period.The acute period and the recovery period were divided according to the onset time,symptoms,signs and imaging performance peripheral venous blood samples of the three groups were collected to measure platelet parameters separately,including platelet count(PLT),platelet distribution width(PDW),mean platelet volume(MPV),platelet hematocrit(PCT)and platelet-large cell ratio(P-LCR).The t-test and F-test were used to compare the differences between groups.Results The various parameters of platelet were statistically significant in acute and recovery phase in SMPP group[PLT(242.06±62.44)×10 9/L,PDW(10.74±2.34)%,MPV(9.58±0.85)fL,PCT(0.25±0.09)%,P-LCR(22.21±5.98)%and PLT(405.11±101.00)×10 9/L,PDW(9.87±1.67)%,MPV(9.22±0.67)fL,PCT(0.37±0.09)%,P-LCR(20.07±3.23)%;t=-13.02,2.87,3.14,-8.65,2.30;P<0.05 for each].Compared with the control group in acute phase,the levels of PLT and PCT in SMPP group were significantly decreased,and in MPP group were significantly increased,the differences were statistically significant[the statistics of SMPP group,MPP group and control group were PLT(242.06±62.44)×10 9/L,(333.28±92.60)×10 9/L,(287.36±36.29)×10 9/L and PCT(0.25±0.09)%,(0.32±0.12)%,(0.28±0.05)%;F=40.67,18.52;P<0.05 for each].Compared with the control group in recovery phase,the levels of PLT and PCT in SMPP and MPP group were significantly increased,the differences were statistically significant[the statistics of SMPP group,MPP group and control group were PLT(405.11±101.00)�

关 键 词：肺炎 支原体 儿童 血小板 

分 类 号：R725.6[医药卫生—儿科]