丹参酮ⅡA对慢性肺源性心脏病急性加重期患者脑钠肽、D-二聚体的影响  

Effect of tanshinone ⅡA on brain natriuretic peptide and D-dimmer levels in patients with chronic pulmonary heart disease in acute exacerbation stage

作　　者：初巍巍 张志 刘熠[1] 宫丹丹[2] CHU Weiwei;ZHANG Zhi;LIU Yi;GONG Dandan(Third Department of Cardiology,Dalian Third People's Hospital,Dalian 116031,Chin;Third Department of Cardiology,Dalian Central Hospital,Dalian 116000,China)

机构地区：[1]大连市第三人民医院心内三科,辽宁大连116031 [2]大连市中心医院心内三科,辽宁大连116000

出　　处：《中国现代医生》2018年第8期1-3,34,共4页China Modern Doctor

摘　　要：目的探讨丹参酮ⅡA对慢性肺源性心脏病急性加重期的疗效及对患者脑钠肽、D-二聚体水平的影响。方法选择2015年1月~2017年1月收治的83例慢性肺源性心脏病急性加重期患者,分为研究组和对照组。对照组41例患者采用常规治疗方法,同时给予贝拉普利治疗,研究组42例患者在对照组治疗基础上给予丹参酮ⅡA静脉滴注治疗,比较两组患者治疗效果及对患者脑钠肽、D-二聚体水平的影响。结果研究组有效率(85.71%)显著高于对照组(65.85%),差异有统计学意义(P<0.05);两组患者治疗后氧分压(PaO_2)、二氧化碳分压(PaCO_2)、血氧饱和度(SaO_2)指标与治疗前比较,差异有统计学意义(P<0.05);研究组治疗后PaO_2、PaCO_2指标改善程度优于对照组(P<0.05);两组患者治疗后LVEF显著高于治疗前,脑钠肽、D-二聚体指标显著低于治疗前,差异有统计学意义(P<0.05);研究组LVEF、脑钠肽、D-二聚体指标改善程度显著优于对照组(P<0.05)。结论丹参酮ⅡA治疗慢性肺源性心脏病急性加重期的疗效确切,能有效提高心功能,降低血清脑钠肽水平,改善血液循环。Objective To explore the effects of tanshinoneⅡA on the treatment of chronic patients with pulmonary heart disease in acute exacerbation stage,and to study its effects on brain natriuretic peptide and D-dimer levels.Methods A total of 83 patients with chronic pulmonary heart disease in acute exacerbation stage who admitted in our hospital from January 2015 to January 2017 were selected and divided into study group and control group,41 cases in the control group were given conventional treatment and Belapril treatment,and the 42 patients in the study group were given tanshinoneⅡA intravenous infusion therapy on the basis of the control group.The therapeutic efficacy and the effects on the brain natriuretic peptide and D-dimer levels of two groups were compared.Results The effective rate(85.71%)in the study group was significantly higher than that(65.85%)in the control group,and the difference was statistically significant(P<0.05).There were significant differences in partial pressure of oxygen(PaO2),carbon dioxide partial pressure(PaCO2)and oxygen saturation(SaO2)index after treatment compared with those before treatment in two groups(P<0.05).The improvement of PaO2 and PaCO2 indexes after treatment in the study was better than that in the control group(P<0.05).The LVEF level in two groups after treatment was significantly higher than that before treatment,and the brain natriuretic peptide and D-dimmer levels in two groups after treatment were significantly lower than those before treatment(P<0.05).The improvement of LVEF,brain natriuretic peptide and D-dimmer levels in the study group was significantly better than that in the control group(P<0.05).Conclusion TanshinoneⅡA has exact effect in treatment of patients with chronic pulmonary heart disease in acute exacerbation stage,it can effectively improve heart function,reduce serum brain natriuretic peptide level,and can improve blood circulation.

关 键 词：丹参酮ⅡA 肺源性心脏病 急性加重期 脑钠肽 D-二聚体 

分 类 号：R541.5[医药卫生—心血管疾病]