鼠神经生长因子注射液与维生素B12注射液治疗糖尿病周围神经病变的疗效观察  

Comparison of rat nerve growth factor injection and vitamin B12 injection in the treatment of diabetic peripheral neuropathy

作　　者：黄有胜[1] 刘玲玲 Huang Yousheng(Dongguan Humen Hospital,Dongguan 523900,China)

机构地区：[1]东莞市虎门医院,523900 [2]不详

出　　处：《国际医药卫生导报》2018年第7期1050-1052,共3页International Medicine and Health Guidance News

摘　　要：比较鼠神经生长因子注射液与维生素B12注射液治疗糖尿病周围神经病变（DPN）的临床疗效。方法 选择2015年6月至2017年6月神经科接诊的100例糖尿病周围神经病变患者，分为观察组和对照组，均接受糖尿病基础治疗，对照组患者追加维生素B12注射液治疗，观察组患者追加鼠神经生长因子注射液治疗，比较两组患者疗效。结果 观察组DPN患者治疗有效率显著高于对照组（94%比82%），差异有统计学意义（P＜0.05）。观察组与对照组治疗前MNCV和SNCV的正中神经和腓总神经水平比较差异无统计学意义（P＞0.05）；治疗后，观察组MNCV和SNCV的正中神经和腓总神经水平提高幅度大于对照组，差异有统计学意义（P＜0.05）。观察组不良反应发生率低于对照组（2.0%比4.0%），差异无统计学意义（P＞0.05）。结论 鼠神经生长因子治疗糖尿病周围神经病变的疗效显著，前者有提高神经传导速度的作用，且不良反应小，值得临床推广。To compare the clinical efficacy of rat nerve growth factor injection and vitamin B12 injection in the treatment of diabetic peripheral neuropathy.Methods 100 cases of patients with diabetic peripheral neuropathy admitted to department of neurology from June 2015 to June 2017 were divided into observation group and control group.The two groups were treated with basic treatment,the control group was treated with vitamin B12 injection on the basis,the observation group was treated with rat nerve growth factor injection.The curative effect was compared between the two groups.Results The effective rate of treatment of DPN in the observation group was 94%,which was significantly higher than that of the control group(82%),with statistically significant difference(P<0.05).There were no statistically significant differences in MNCV and SNCV of the median nerve and peroneal nerve between the observation group and the control group before treatment(P>0.05);after treatment,MNCV and SNCV of the median nerve and peroneal nerve in the observation group increased more significantly than those in the control group,with statistically significant differences(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the observation group and the control group(2%vs.4%,P>0.05).Conclusion The effect of rat nerve growth factor on diabetic peripheral neuropathy is significant,which has the effect of improving nerve conduction velocity,with little side effect,worthy of clinical promotion.

关 键 词：鼠神经生长因子 维生素B12 糖尿病周围神经病变 

分 类 号：R587.2[医药卫生—内分泌]