齐墩果酸聚合物胶束的制备及质量研究  

Study on preparation and quality of oleanolic acid polymer micelle system

作　　者：史琼[1] 王苇 程铁峰[1] SHI Qiong;WANG Wei;CHENG Tiefeng(Institute of Pharmacy of Henan University,Kaifeng 475000,China)

机构地区：[1]河南大学药学院,河南开封475000

出　　处：《河南大学学报（医学版）》2018年第1期18-22,共5页Journal of Henan University:Medical Science

摘　　要：[目的]制备齐墩果酸聚合物胶束,并对其质量进行评价。[方法]采用透析法制备齐墩果酸聚合物胶束,通过正交设计实验确定最优处方。对聚合物胶束形态和粒径和稳定性进行确定,建立高效液相方法对聚合物胶束进行含量、溶解度、溶出度的测定,研究聚合物胶束的增溶效果。[结果]按筛选出的最优处方制备的胶束粒径为(64.24±2.64)nm,PDI为0.093±0.02,包封率为(87.06±1.45)%,载药量为(10.22±0.9)%。溶解度为0.689 04 g/L,60 min时溶出度为80.6%。[结论]通过正交实验筛选处方制备出了粒径分布均匀,包封率和载药量较高,溶解度和溶出度显著提高并且稳定性良好的胶束。〔Objective〕To prepare oleanolic acid polymer micelles and evaluate their quality.〔Methods〕Oleanolic acid polymer micelles were prepared by dialysis method,and the optimal formula was determined by orthogonal design.The morphology and size of polymer micelles were determined,Estabalish HPLC method to determine the content,solubility and dissolution of polymer micelles,and the solubilization effect of polymer micelles was studied.〔Results〕The size of the micelles prepared by the best formula was(64.24±2.64)nm,PDI was(0.093±0.02),entrapment efficiency was(87.06±1.45)%,and drug loading was(10.22±0.9)%.The solubility is 0.689 04 g/L and the dissolution rate is 80.6%at 60 min.〔Conclusion〕The spherical micelles with uniform size distribution,high encapsulation efficiency,high drug loading,high solubility and dissolution can be prepared by orthogonal test.

关 键 词：齐墩果酸 聚合物胶束 含量测定 溶解度 溶出度 

分 类 号：R944.2[医药卫生—药剂学]