羟基脲引发下肢溃疡的机制研究和进展  

Mechanism and Progress of Hydroxyurea-Induced Lower Limb Ulcer

作　　者：赵倩楠 刘若璇 张舒曼 周粤闽 吕玉泉[2] ZHAO Qiannan;LIU Ruoxuan;ZHANG Shuman;ZHOU Yuemin;LYU Yuquan(Department of Plastic and Reconstructive Surgery,Huaihe Hospital of Henan University,Kaifeng 475000,China;Department of Social Medicine,Osaka University Graduate School of Medicien,Osaka 565-0871,Japan)

机构地区：[1]河南大学淮河医院整形修复外科,河南开封475000 [2]大阪大学大学院医学系,日本大阪565-0871

出　　处：《河南大学学报（医学版）》2018年第1期69-72,共4页Journal of Henan University:Medical Science

基　　金：河南省医学科技攻关计划省部共建项目(201401014)

摘　　要：羟基脲(hydroxyurea,HU)作为一种抗肿瘤药,常用于治疗镰状细胞性贫血(SCD)和费城染色体阴性(BCRABL1)骨髓增殖性肿瘤(MPN)。随着其临床应用的不断扩大,长期服用羟基脲导致不良反应的报道也越来越多。下肢溃疡作为HU引发的罕见不良反应,其诊断是困难的。因此,常常延误治疗时机。本文旨在综述HU引发下肢溃疡的临床特点和作用机制,为临床治疗提供参考。〔Objective〕〔Methods〕〔Results〕〔Conclusion〕As an antitumor drug,hydroxyurea(HU)is mainly used in the treatment of sickle-cell disease and Philadelphia chromosome-negative myeloproliferative neoplasm.Along with the development of clinical applications,more and more adverse reactions caused by long-term administration of HU have been reported.Lower limbs ulcer,a rare adverse reaction caused by HU,is difficult to diagnose and coneequently get appropriate treatment in time.The purpose of this review is to summarize the clinical characteristics and mechanism of Lower limbs ulcers associated with HU therapy and provide references for clinical treatments.

关 键 词：羟基脲 下肢溃疡 作用机制 皮肤副作用 

分 类 号：R979.1[医药卫生—药品]