高分子材料椎间融合器的应用现况  

Application of polymer interbody fusion cages

作　　者：王鹏[1] 孙桂森[1] 李红旗[1] 郭隆升[1] 郎明磊[1] 刘文军[1] 范伟强[1] Wang Peng;Sun Gui-sen;Li Hong-qi;Guo Long-sheng;Lang Ming-lei;Liu Wen-jun;Fan Wei-qiang(Department of Spinal Surgery,Central Hospital of Shengli Oilfield,Dongying 257000,Shandong Province,China)

机构地区：[1]胜利油田中心医院脊柱外科,山东省东营市257000

出　　处：《中国组织工程研究》2018年第2期310-315,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:椎间融合是脊柱外科中行之有效的治疗手段,经典的自体/异体植骨融合具有较高的融合率,但同时也存在诸多不足。近年来高分子材料椎间融合器逐渐应用于临床,为脊柱外科医师提供了更多的选择。目的:以材料学特性为切入点,分别介绍常用可吸收高分子材料与不可吸收高分子材料的优越性和局限性,并进一步展望其应用前景。方法:应用计算机检索Pub Med、Ovid及中国知网等数据库,着重检索现阶段常用医用高分子材料的特性及其在脊柱外科中的应用现状,检索中文关键词为"脊柱外科,融合器,工程塑料,可降解高分子材料",英文关键词为"spinal surgery,fusion cage,engineering plastic,degradable high polymer material",根据阅读检索的文献进一步追索各种高分子材料的材料特性及应用现状。结果与结论:目前,各种高分子材料特别是可降解有机高分子材料尚处于探索和初步研究阶段,部分新材料的动物实验和生物力学实验等临床前研究仍有待于逐步深入。目前除聚醚醚酮材料椎间融合器在临床广泛使用外,一些研究较早、认识较充分的高分子材料在进一步推广应用前仍然缺乏大样本、多中心的临床试验。BACKGROUND:Interbody fusion is an effective approach in the spinal surgery which is traditionally performed via auto/allogenic bone grafting,and it has a number of shortcomings as well as specific therapeutic effects.In the past few years,polymer interbody fusion cages have been gradually applied in clinical practice,which provides more options for spinal surgeons.OBJECTIVE:To introduce the advantages and disadvantages of degradable/non-degradable polymer materials respectively by analyzing their materialogy characteristics,and to further predict their application prospects.METHODS:PubMed,Ovid and CNKI were searched by computer to retrieve articles concerning the materialogy characteristics and application situation of common biomedical polymer materials in the spinal surgery.The key words were“spinal surgery,fusion cage,engineering plastic,degradable high polymer material”in Chinese and English,respectively.RESULTS AND CONCLUSION:Up to now,a variety of polymer materials,especially degradable polymer materials,are still at the stage of exploring and primary research,and their in-depth studies,including animal and biomechanics experiments,are still expected to be done gradually.Except for PEEK interbody fusion cages,some polymer materials are still lack of large sample and multi-center clinical trials before further application.

关 键 词：生物相容性材料 脊柱融合术 组织工程 

分 类 号：R318[医药卫生—生物医学工程]