甲基丙烯酸酐明胶材料学特性及在皮肤组织工程应用与进展  

Properties of gelatin methacryloyl and its application in the skin tissue engineering

作　　者：吴兴[1] 刘肇兴 林欢欢 刘沙[2] 孙伟晶[2] 陈向军[2] Wu Xing;Liu Zhao-xing;Lin Huan-huan;Liu Sha;Sun Wei-jing;Chen Xiang-jun(Inner Mongolia Medical University,Hohhot 010110,Inner Mongolia Autonomous Region,China;Department of Burn and Plastic Surgery,the 253rd Hospital of PLA,Hohhot 010010,Inner Mongolia Autonomous Region,China)

机构地区：[1]内蒙古医科大学,内蒙古自治区呼和浩特市010110 [2]解放军第二五三医院烧伤整形科,内蒙古自治区呼和浩特市010010

出　　处：《中国组织工程研究》2018年第2期323-328,共6页Chinese Journal of Tissue Engineering Research

摘　　要：背景:甲基丙烯酸酐明胶具有合适的生物学特性、可调谐的理化特性、无细胞毒性的和非免疫原性,被广泛应用于组织工程领域。目的:总结甲基丙烯酸酐明胶水凝胶材料的性能及应用于皮肤软组织损伤的最新研究进展。方法:在Pub Med和Sci Finder中检索2007年1月至2017年8月发表的与甲基丙烯酸酐明胶水凝胶相关的文献,检索关键词为:seed cell,skin regeneration,wound vascularization,gelatin,gelatin methacryloyl,scaffold material,wound healing,microenvironment,tissue construction,skin tissue engineering。结果与结论:甲基丙烯酸酐明胶水凝胶与天然细胞外基质的特性非常相似,具有细胞黏附位点、基质金属蛋白酶反应肽基序列和可交联特性,表现出良好的组织亲和性,具有可调节的物理化学性质、一定的黏合性及可降解性,使其成为理想的细胞支架,允许各类细胞在其表面增殖和扩散。因此甲基丙烯酸酐明胶水凝胶在皮肤组织工程中有广阔的发展前景,可加速创面血管化和上皮组织再生,提高创面愈合速度,减少感染概率,提升患者生活质量,其可为烧伤创面治疗和战创伤救治提供一种高效、便携的凝胶敷料,还可用于填充外伤和溃疡等皮肤软组织缺损、术后美容切口的覆盖等。BACKGROUND:Gelatin methacryloyl has been widely used in the field of tissue engineering,as it has suitable biological properties,tunable physical and chemical properties,non-cytotoxic and non-immunogenicity.OBJECTIVE:To summarize the latest advances in the repair of skin and soft tissue damage using gelatin methacryl hydrogel materials.METHODS:PubMed and SciFinder were retrieved for articles concerning gelatin methacrylate hydrogels published from January 2007 to August 2017.The key words were“seed cell,skin regeneration,wound vascularization,gelatin,gelatin methacryloyl,scaffold material,wound healing,microenvironment,tissue construction,skin tissue engineering”.RESULTS AND CONCLUSION:The gelatin methacryloyl hydrogel is very similar to the native extracellular matrix,and has a cell adhesion site,a matrix metalloproteinase-reactive peptide-based sequence and a cross-linkable property exhibiting good tissue affinity.The hydrogel has adjustable physical and chemical properties,a certain degree of adhesion and biodegradability,which make it an ideal cell scaffold,allowing all kinds of cells to proliferate and extend on its surface.Therefore,gelatin methacrylamide hydrogel has broad prospects in the skin tissue engineering,which can accelerate wound vascularization and epithelial tissue regeneration,improve wound healing rate,reduce the probability of infection,and improve the patient’s quality life.The gelatin methacrylamide hydrogen is proved to provide an efficient and portable gel dressing for burn wounds and war wounds,and it can also be used to fill skin and soft tissue defects such as trauma and ulcers,and cover cosmetic incisions.

关 键 词：皮肤 新生血管化 生理性 明胶 组织工程 

分 类 号：R318[医药卫生—生物医学工程]