彩色多普勒超声联合血清HMGB1及ROMA指数鉴别绝经后女性盆腔包块性质  

Value of color Doppler ultrasonography combined with serum HMGB1 and ROMA indexes in early differential diagnosis of pelvic mass in postmenopausal women

作　　者：李娟娟[1] LI Juan-juan(Ultrasonic Department,Women&Infants Hospital of Zhengzhou City,Zhengzhou,Henan 450000,China)

机构地区：[1]郑州市妇幼保健院超声诊断科,河南郑州450000

出　　处：《实用医药杂志》2018年第2期116-118,共3页Practical Journal of Medicine & Pharmacy

摘　　要：目的探究彩色多普勒超声联合血清HMGB1及ROMA指数对绝经后女性盆腔包块早期鉴别诊断的价值。方法选取盆腔包块绝经妇女117例,病理组织学分为65例良性病变组和52例卵巢癌组,对卵巢癌组进行临床分期;电化学法检测CA125浓度,ELISA法检测HE4和HMGB1水平,依据CA125和HE4计算绝经后ROMA指数;依据Timmerman标准判读彩超结果 ;以病理组织学为金标准,分析单独检测及联合诊断对盆腔包块性质鉴别的诊断性能。结果彩超指标如单双侧病灶、血流分级及包块直径均与包块良恶性密切相关;卵巢癌患者血清CA125、HMGB1、HE4浓度及ROMA指数均显著高于卵巢良性病变组,且以上指标在Ⅲ+Ⅳ期患者组中显著高于Ⅰ+Ⅱ期卵巢癌患者,差异有统计学意义;联合彩超与HMGB1和ROMA方案诊断灵敏度、特异度和阴阳性预测值均较单一诊断方案显著提高。结论联合彩超与HMGB1和ROMA方案可作为临床鉴别绝经后妇女盆腔包块性质的可行方法。Objective To investigate the value of color Doppler ultrasonography combined with serum HMGB1 and ROMA indexes in the early differential diagnosis of pelvic mass in postmenopausal women.Methods The 117 postmenopausal women with pelvic mass were divided into benign lesions group(n=65)and ovarian cancer group(n=52)based on their histopathology findings;and ovarian cancer group were also codified by clinical staging.Concentration of CA125 was detected by electrochemical method,and levels of HE4 and HMGB1 were measured by ELISA.ROMA index was calculated based on CA125 and HE4 data.Color Doppler ultrasound results were judged according to Timmerman standard.Compared with results of histopathology,which was as the gold standard,the diagnostic performance of single detection and combined diagnosis was analysed by using multiple indexes for identifying pelvic mass.Results The color Doppler indexes such as single bilateral lesions,blood flow grade and mass diameter were closely related to the identification of pelvic mass.CA125,HMGB1,HE4 concentration and ROMA index in ovarian cancer patients were significantly higher than those in the benign lesion group,and the above indexes in ovarian cancer patients atⅢ+Ⅳstage were also significantly higher in the patients with this cancer.The sensitivity,specificity and negative predictive value for program combined HMGB1,color Doppler ultrasound and ROMA diagnostic were significantly improved when compared with the single diagnosis program.Conclusion The program combined with ultrasonography,HMGB1 and ROMA can be used as a feasible method for clinical identification of pelvic mass in postmenopausal women.

关 键 词：盆腔包块 卵巢癌 彩色多普勒超声 ROMA指数 HMGB1 

分 类 号：R445.1[医药卫生—影像医学与核医学] R737.3[医药卫生—诊断学]