过敏性紫癜肾损害的早期诊断  

Early Diagnosis of Henoch Schonlein Purpura Renal Lesions

作　　者：沈小雄 肖小妹 朱云霏 王玲[3] SHEN Xiao-xiong;XIAO Xiao-mei;ZHU Yun-fei;WANG Ling(Postgraduate Student in Grade 2015,Gannan Medical University,GanZhou,JiangXi 341000;Dept.of Pediatrics,Ganzhou People's Hospital,GanZhou,JiangXi 341000;Dept.of Pediatrics,the First Affiliated Hospital of Gannan Medical university,GanZhou,JiangXi 341000)

机构地区：[1]赣南医学院,江西赣州341000 [2]赣州市人民医院儿科,江西赣州341000 [3]赣南医学院第一附属医院儿科,江西赣州341000

出　　处：《赣南医学院学报》2018年第2期195-199,共5页JOURNAL OF GANNAN MEDICAL UNIVERSITY

摘　　要：过敏性紫癜(Henoch-Schonlein purpura,HSP)是一种系统性血管异常免疫反应性疾病,且以小血管炎病变为主,儿童期最为常见。HSP可侵犯多个系统,若病变累及肾脏,引起肾脏损害则称为过敏性紫癜肾炎(Henochschonlein purpura nephritis,HSPN)。肾脏受损及其受损严重程度是决定预后的关键因素,因此早发现、早干预、早治疗肾损害对HSP患儿取得良好预后具有重要意义。近年来不少学者研究发现血半乳糖缺陷性Ig A1、胰岛素样生长因子1、胰岛素样生长因子结合蛋白3、正五聚蛋白3、toll样受体4等;尿胱抑素C、中性粒细胞明胶酶相关脂质运载蛋白、尿微蛋白等在提示HSP早期肾脏损害方面可能发挥了重要作用。本文就这些研究进展作一综述。Henoch-schonlein purpura(HSP)is a systemic vascular abnormal immune reaction disease with small vasculitis as the main lesion in childhood.HSP can invade multiple systems.If the lesion involves the kidney,the kidney damage is called henoch-schonlein purpura nephritis(HSPN).Renal damage and its severity are key factors in determining prognosis,so early detection,early intervention and early treatment of renal impairment are of great significance to achieve a good prognosis in children with HSP.In recent years,many scholars have found that blood galactose deficient IgA1,insulin-like growth factor 1,insulin-like growth factor-binding protein 3,Pentraxin 3,TLR4,Urinary cystatin C,Neutrophil gelatinase associated lipid carrier protein and urine microprotein play an important role in the early renal injury of HSP.This article reviews the progress of these studies.

关 键 词：过敏性紫癜 过敏性紫癜肾炎 

分 类 号：R554.6[医药卫生—血液循环系统疾病]