微反应器中三羟甲基丙烷的制备  

Preparation of Trimethylolpropane in a Microreactor

作　　者：王克军 周峰[1,2] 刘宏臣 温正慧[1,2] 陈光文 Wang Kejun;Zhou Feng;Liu Hongchen;Wen Zhenghui;Chen Guangwen(Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian 116023,China;University of Chinese Academy of Sciences,Beijing 100049,China)

机构地区：[1]中国科学院大连化学物理研究所,辽宁大连116023 [2]中国科学院大学,北京100049

出　　处：《化学反应工程与工艺》2017年第6期481-486,共6页Chemical Reaction Engineering and Technology

基　　金：国家自然科学基金项目(U1608221;U1662124;21506205);科技部重点领域创新团队(2016RA4053);大连化物所科研创新基金资助(DICP ZZBS201706)

摘　　要：为改进间歇釜式合成三羟甲基丙烷(TMP)反应过程中所存在的耗时长、收率低等问题,研究了在微反应器中采用Cannizzaro歧化法连续高效合成TMP的工艺过程。实验考察了停留时间、反应温度、氢氧化钠/正丁醛物质的量比、甲醛/正丁醛物质的量比及正丁醛浓度等工艺参数对TMP收率的影响。结果发现:以氢氧化钠为催化剂、反应温度55℃、正丁醛浓度2.0 mol/L、甲醛与正丁醛物质的量比为5.0、氢氧化钠与正丁醛物质的量比为1.0及停留时间500 s的优化条件下,TMP收率可达85.9%,具有较好的工业应用前景。In order to improve the time-consuming and low yield problems in the batch reactors for the synthesis of trimethylolpropane(TMP),the continuous and efficient synthesis of TMP using the Cannizzaro disproportionation process in a microreactor was studied.The effects of process parameters such as residence time,reaction temperature,the molar ratio of sodium hydroxide to n-butanal(M-ratioSB),the molar ratio of formaldehyde to n-butanal(M-ratioFB),and n-butanal concentration on the yield of TMP were investigated.The optimal parameters were determined as follows:sodium hydroxide as catalyst,reaction temperature 55℃,n-butanal concentration 2.0 mol/L,M-ratioFB 5.0,M-ratioSB 1.0 and residence time 500 s,85.9%yield of TMP can be obtained under these optimal conditions,which has a good industrial application prospect.

关 键 词：微反应器 微通道 正丁醛 三羟甲基丙烷 CANNIZZARO反应 

分 类 号：TQ22[化学工程—有机化工]