早孕绒毛及蜕膜组织中酪氨酸磷酸酶-1/2(SHP-1,SHP-2)与吲哚胺2,3-双加氧酶(IDO)的表达及其相关性  

Correlation of tyrosine phosphatase-1/2( SHP-1,SHP-2) with indoleamine 2,3-dioxygenase( IDO) in villi and decidua of early pregnancy

作　　者：袁艳 翁宇红 赵淑云 李仕祥 王珺 谭红梅 杨敏燕 黄官友 谭红梅 YUAN Yan;WENG Yu-Hong;ZHAO Shu-Yun;LI Shi-Xiang;WANG Jun;TAN Hong-Mei;YANG Min-Yan;HUANG Guan-You;TAN Hong-Mei(Affiliated Hospital of Guizhou Medical University,Guiyang 550004,China)

机构地区：[1]贵州医科大学附属医院,贵阳550004 [2]贵阳市开阳县人民医院,开阳550300

出　　处：《中国免疫学杂志》2018年第4期513-515,519,共4页Chinese Journal of Immunology

基　　金：本文受国家自然科学基金(81360452)资助。

摘　　要：目的:研究母胎界面中吲哚胺2,3-双加氧酶(IDO)及酪氨酸磷酸酶-1/2(SHP-1,SHP-2)的表达及其相关性,以探索母胎免疫耐受的新机制。方法:30例正常早孕6~8周妇女行人工流产获取绒毛及蜕膜组织,用Western blot方法检测绒毛、蜕膜组织中的酪氨酸磷酸酶-1/2(SHP-1、SHP-2)与IDO的蛋白表达,分析IDO与SHP-1、SHP-2的相关性。结果:人早孕绒毛及蜕膜组织中均有SHP-1、SHP-2的表达,与IDO的表达呈正相关;SHP-1、SHP-2和IDO在蜕膜组织中的表达均高于绒毛;结论:在正常生理妊娠状态下,母胎界面中SHP-1、SHP-2可能参与调节IDO的表达,在维持母胎界面的免疫耐受状态起着重要作用。Objective:To explore the correlation of tyrosine phosphatase-1/2(SHP-1,SHP-2)with indoleamine 2,3-dioxygenase(IDO)in maternal fetal interface.Methods:The expression of SHP-1,SHP-2 and IDO were detected by Western blot method and the relationship of the proteins was analysed,in human chorionic villi and decidua tissues of 30 cases of artificial abortion patients.Results:The expression of SHP-1,SHP-2 were positively correlated withthe expression of IDO in human chorionic villi and decidua;the expression of SHP-1,SHP-2 and IDO in decidual tissues were higher than those in the villi.Conclusion:Normal physiological state of pregnancy,SHP-1 and SHP-2 may be involved in the regulation of immune tolerance by positive regulation of IDO expression at maternal fetal interface.

关 键 词：吲哚胺2 3-双加氧酶 蛋白质酪氨酸磷酸酶 绒毛 蜕膜 

分 类 号：R714.2[医药卫生—妇产科学] R392.3[医药卫生—临床医学]