某院近3年药品不良反应事件与超药品说明书用药现状及相关性研究  

Study on Current Status and Correlation Between Drug Adverse Events and Off-Label Drug Use in a Hospital in Last 3 Years

作　　者：叶红[1] Ye Hong(Departent of Pharmacy,Bazhong Hospital of Traditional Chinese Medicine,Sichuan,China 636000)

机构地区：[1]四川省巴中市中医院药学部,四川巴中636000

出　　处：《中国药业》2018年第3期81-83,共3页China Pharmaceuticals

摘　　要：目的了解超药品说明书用药现状,探讨药品不良反应事件(ADE)与其相关性。方法统计某院2014年1月至2016年12月的ADE及超药品说明书用药情况,并分析两者的相关性。结果 330例ADE患者共发生器官/系统损害497例次,其中以皮肤及其附件受损害最多,占57.95%;415例超药品说明书用药医嘱中,发现450项超说明书用药类型,其中以超单次剂量和超给药频次最多见,分别占33.78%和34.22%。超药品说明书用药与ADE发生时间及受累器官/系统具有相关性(P<0.05)。结论超药品说明书用药与ADE的发生具有相关性,相应政府部门需加大监管力度。Objective To understand the current status of Of-label drug use,and investigate the coorelation between adverse drug events(ADE)and o ff-la b e l drug use.M ethods ADE and o f-label drug use in a hospital from January 2014 to December 2016 were statistically analyzed,and the correlation between ADE and off-label drug use was analyzed.R esults In 330 patients with ADE,497 cases of organ or systemic injuries were found,among which skin and accessory injuries were the most,accounting for 57.9 5%.In 415 cases of off-label medication orders,a total of 450 types of directions were found,among which the frequencies of off-single dose and over dosage were the highest,accounting for 33.78%and 34.22%,respectively.There was a correlation between o ff-la b e l drug use and the duration of ADE and involved organ or system(P<0.0 5).C onclusion There is a correlation between off-label drug use and the occurrence of ADE,and the corresponding government departments should strengthen supervision.

关 键 词：药品不良反应 超药品说明书用药 合理用药 用药现状 

分 类 号：R969.3[医药卫生—药理学] R954[医药卫生—药学]