顺式阿曲库铵闭环肌松输注与传统间断给药对老年患者肌松恢复的影响  

Comparison of neuromuscular blockade recovery between close-loop muscle relaxant injection and intermittent bolus injection in elderly patients

作　　者：黄井林[1] 辜敏[1] 邹恒婧 李佳[1] 党亮 江敏[1] HUANG Jing-lin;GU Min;ZOU Heng-jing;LI Jia;DAN Liang;JIANG Min(Department of Anesthesiology,Chengdu First People s Hospital,Chengdu 610041 China)

机构地区：[1]成都市第一人民医院麻醉科,四川成都610041

出　　处：《实用医院临床杂志》2018年第2期38-40,共3页Practical Journal of Clinical Medicine

基　　金：四川省卫生厅科研基金资助项目(编号:120523)

摘　　要：目的比较顺式阿曲库铵经闭环肌松输注系统和传统间断给药用于老年患者的效果。方法选择年龄≥60岁全身麻醉下行择期骨科手术的患者30例,根据随机数字表分为对照组与闭环组各15例。对照组采用传统间断静脉推注给药,闭环组经闭环肌松输注系统自动给药。麻醉诱导使用丙泊酚与舒芬太尼,维持采用静吸复合麻醉。观察两组肌松起效、维持和恢复时间。结果两组患者肌松起效和维持时间差异无统计学意义(P>0.05)。闭环组TOFr恢复至0.2、0.5、0.7、0.9的时间明显短于对照组,差异有统计学意义(P<0.05)。结论与传统间断推注相比,闭环输注用于老年患者起效时间和维持时间相当,但术后肌松早期恢复比间断静脉推注快。To determine whether administration of cis-atracurium via close-loop muscle relaxant injection system(CLMRIS)is superior to conventional intermittent bolus injection in elderly patients.Thirty patients(≥60 years old)who received elective orthopedics surgery under general anesthesia were randomly divided into group 1 and 2,15 in each group.Patients in the group 1 were induced and maintained with intermittent bolus injection of cis-atracurium while patients in the group 2 with automatic administration by CLMRIS.Propofol and sufentanil were use for induction of anesthesia and combined intravenous-inhalation anesthesia for maintenance.There was no statistically significant difference in the time of onset and duration of drug effect(P>0.05).The time of TOFr recovery to 0.2,0.5,0.7 and 0.9 in the group 2 was significant shorter than that in the group 1(P<0.05).Compared to intermittent bolus injection,administration via CLMRIS is comparable in onset time and duration of neuromuscular blockade.However,its early recovery is more rapid.

关 键 词：顺式阿曲库铵 闭环肌松输注系统 肌松监测 老年 

分 类 号：R614[医药卫生—麻醉学]