亚胺培南西司他丁不同滴注速度对重症肺炎疗效的影响  

Effect of different infusion rates of imipenem and ulinastatin on severe pneumonia

作　　者：宋磊[1] 陈红[1] 杜月君 徐治波[1] 冯薇[2] SONG Lei;CHEN Hong;DU Yue-jun(the second people′s Hospital of Chengdu,Chengdu 610017,China;Affiliated Hospital of Chengdu University,Chengdu 610081,China)

机构地区：[1]成都市第二人民医院,四川成都610017 [2]成都大学附属医院,四川成都610081

出　　处：《吉林医学》2018年第4期612-615,共4页Jilin Medical Journal

基　　金：成都市卫生和计划生育委员会课题[课题编号:2016013]

摘　　要：目的:研究亚胺培南西司他丁通过延长滴注时间治疗重症肺炎的疗效观察。方法:66例重症肺炎患者,按照随机抽样分为两组,每组33例。试验组给予亚胺培南西司他丁1 g/2 h滴注,每8小时给药1次;对照组给予亚胺培南西司他丁1/0.5h滴注,每8小时给药1次。两组均通过微泵泵入的方式控制滴注速度。两组均给予祛痰、生命支持及营养支持等对症治疗。比较两组临床疗效、细菌清除率、平均住院时间。结果:(1)炎性指标的观察:试验组CRP由治疗前的(98.94±23.73)mg/L降至(8.31±4.66)mg/L,对照组由治疗前的(98.75±20.98)mg/L降至(21.85±11.80)mg/L。两组治疗前比较,差异无统计学意义(P>0.05);治疗后两组比较,试验组优于对照组,差异具有统计学意义(P<0.05)。试验组PCT由治疗前的(5.04±1.99)ng/ml降至(0.38±0.25)ng/ml;对照组由治疗前的(5.02±1.87)ng/ml降至(0.62±0.32)ng/ml。两组治疗前比较,差异无统计学意义(P>0.05);治疗后两组比较,试验组优于对照组,差异具有统计学意义(P<0.05)。(2)细菌清除率比较:试验组细菌清除率82.8%,对照组细菌清除率71.4%的清除率,两组比较,差异具有明显统计学意义(P<0.05)。(3)临床疗效比较:试验组有效率为84.8%,对照组有效率为67.7%;两组比较,差异有统计学意义(P<0.05)。(4)平均住院天数比较:试验组平均住院天数为(10.5±1.7)d,对照组平均住院天数(12.2±1.9)d,两组差异具有统计学意义(P<0.05)。结论:亚胺培南2 h滴注给药的方式对重症肺炎的疗效优于0.5 h滴注给药的方式。Objective To investigate the efficacy of different infusion durations of imipenem cilastatin in the treatment of severe pneumonia.Method 66 cases of patients with severe pneumonia,according to arandom sample divided into two groups,each group includ 33 cases.Experimentalgroup was imipenem cilastatin 1 g/2 h infusion per 8 h administration 24 h;thecontrol group imipenem cilastatin 1/0.5 h infusion administered per 8 h administration 24 h,all were pumped through the micro-pump approach.Other treatmentswere expectorant,life support and nutritional support and other symptomatic treatment.The clinical efficacy,the bacterial clearance rate and the average hospitalization time of the two groups were compared.Results①The comparisonof inflammatory indicators:C-reactive protein in the experimental group from(98.94±23.73)mg/L decreased to(8.31±4.66)mg/L,in the control group from(98.75±20.98)mg/L decreased to(21.85±11.80)mg/L;Before treatment,thedifference was not statistically significant in the two groups(P>0.05),after treatment,the experimental group was better than that of control group,the difference was statisticallysignificant(P<0.05).About PCT,experimental group before treatment(5.04±1.99)ng/ml fell to(0.38±0.25)ng/ml;the control group before treatment(5.02±1.87)ng/ml fell to(0.62±0.32)ng/ml,the two groupstherewas no statistical significance before treatment(P>0.05),the experimental groupwas better than the control group,the differencewasstatistically significant after treatment(P<0.05).②The comparison of bacterial clearance rate:The experimental group bacterial clearance rate was 82.8%,The control bacterialclearance rate was 71.4%,the comparison of two groups had statistical significance difference(P<0.05).③The comparision of clinical curative effect:The experimental group was 84.8%,the control group was 67.7%,the comparison of twogroups had statistical significance difference(P<0.05).④Comparison of average length of stay:The experimental group,the average hospital stay was(10.5±1.7)days for thecont

关 键 词：亚胺培南西司他丁钠 重症肺炎 疗效 

分 类 号：R563.1[医药卫生—呼吸系统]