黄芩拆分组分对正常大鼠物质代谢、能量代谢、内分泌系统及植物神经系统的影响  

The influence on substance and energy metabolism,endocrine system and autonomic nervous system of fraction of Scutellaria baicalensis in normal rats

作　　者：张亚男[1] 陈平平[1] 王洪玉 高鑫[2] 刘树民[2] ZHANG Yanan;CHEN Pingping;WANG Hongyu;GAO Xin;LIU Shumin(Institute of Traditional Chinese Medicine,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Drug Safety EvaluationCenter,Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学中医药研究院,哈尔滨150040 [2]黑龙江中医药大学药物安全评价中心,哈尔滨150040

出　　处：《天津中医药大学学报》2018年第2期137-140,共4页Journal of Tianjin University of Traditional Chinese Medicine

基　　金：国家重点基础研究发展计划(973计划)(2013CB531804);黑龙江中医药大学优秀创新人才支持计划

摘　　要：[目的]通过检测正常大鼠体内物质代谢、能量代谢、内分泌系统及植物神经系统相关酶的含量,考察黄芩拆分组分对其表达的影响,以阐述其寒热属性。[方法]将SD雄性大鼠随机分为空白对照组、全成分组、苷元组、苷类组、多糖组;连续灌胃给药15 d,留取肝脏、心脏、肌肉等脏器,检测物质代谢、能量代谢、内分泌系统及植物神经系统的相关指标。[结果]与空白组相比,黄芩全成分抑制物质代谢、能量代谢、内分泌系统及植物神经系统;苷元和苷类有明显的寒凉药的抑制趋势;多糖组的倾向不明显。[结论]总体来看,黄芩全成分具有寒性,再一次验证了黄芩的寒凉药性;同时可推断苷元和苷类的药性为寒凉,为黄芩寒凉药性的主要物质基础;初步推测多糖的药性可能为微寒,有待于进一步的探究。[Objective]To illuminate the cold and warm property of fraction of Scutellaria baicalensis by detecting related enzyme expression in substance metabolism,energy metabolism,endocrine system and autonomic nervous system in normal rats.[Methods]Fifty male SD rats were randomly divided into blank control group,total composition group,aglycone group,glycosides group,polysaccharide group;All groups were gavaged for 15 days,taking the liver,heart,muscle and detecting the relevant index.[Results]Compared with the blank group,the total composition group of Scutellaria baicalensis can inhibit substance metabolism,energy metabolism,endocrine system and autonomic nervous system,aglycones and glycosides have the the similar trend with the cold medicine polysaccharide group has no obvious tendency.[Conclusion]Overall,the total composition group of Scutellaria baicalensis has cold property and confirm the cold property once again;at the same time we can infer that aglycones and glycosides have cold property and they are the main material basis of Scutellaria baicalensis cold property;polysaccharide has a little cold property and we need to do deep research.

关 键 词：黄芩拆分组分 寒热药性 物质代谢 能量代谢 内分泌系统 植物神经系统 

分 类 号：R289.5[医药卫生—方剂学]