脑血栓片治疗中风病恢复期瘀血阻络证临床疗效观察  

Clinical study of Naoxueshuan tablet against convalescent stroke of blood stagnation obstruction syndrome

作　　者：郭家奎[1] 孙熙罡[1] 吴迪[2] 吕福全[3] 吉学群[4] 熊杰[5] GUO Jiakui;SUN Xigang;WU Di;LYU Fuquan;JI Xuequn;XIONG Jie(The Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine,Tianjin 300250,China;Tianjin Huanhu Hospital,Tianjin 300350,China;Tianjin Nankai Hospital,Tianjin 300100,China;Tianjin Academy of Traditional Chinese Medicine Affiliated Hospital,Tianjin 300120,China;Affiliated Hospital of Logistics College of Chinese People's Armed Police Forces,Tianjin 300162,China)

机构地区：[1]天津中医药大学第二附属医院,天津300250 [2]天津市环湖医院,天津300350 [3]天津市南开医院,天津300100 [4]天津市中医药研究院附属医院,天津300120 [5]武警后勤学院附属医院,天津300162

出　　处：《天津中医药》2018年第4期255-258,共4页Tianjin Journal of Traditional Chinese Medicine

摘　　要：[目的]观察脑血栓片治疗缺血性中风病恢复期瘀血阻络证的临床疗效。[方法]采用多中心、随机对照研究方法,将患者随机分为试验组、对照组,各72例。两组均予基础治疗,对照组口服阿司匹林肠溶片100mg,每日1次,试验组在口服阿司匹林肠溶片基础上服用脑血栓片1.2 g,每日3次,两组均服药12周。在治疗6、12周和纳入后24周,采用美国国立卫生研究院卒中(NIHSS)量表、改良Rankin量表、Barthel指数、脑卒中专门化生存质量(SS-QOL)量表、中医症状积分评价其神经功能、日常生活能力、中医症状等方面的疗效。[结果]两组患者治疗后各时点量表评分均较治疗前好转(P<0.05);试验组总有效率为90.00%,对照组总有效率为73.44%,差异具有统计学意义(P<0.05)。试验组治疗12周时NIHSS量表、Barthel指数、中医症状评分均优于对照组(P<0.05)。试验组随访至纳入后24周时NIHSS量表、Barthel指数、SS-QOL量表、中医症状评分均优于对照组(P<0.05)。改良Rankin量表比较,两组改善情况相当(P>0.05)。[结论]脑血栓片可以有效改善缺血性中风病患者的临床症状,改善神经功能,提高生活质量,其临床疗效确切,值得临床推广应用。[Objective]To observe the clinical efficiency of Naoxueshuan tablets in treating convalescent stroke of blood stagnation obstruction syndrome.[Methods]Patients were divided into experiment group and control group with a multicentre,randomized,and controlled method,72 cases in each group.Patients in both groups all received basic treatment,and Aspirin Enteric-coated tablets 100 mg once a day was applied to control group,while Naoxueshuan tablets 1.2 g three times a day with Aspirin Enteric-coated tablets 100 mg once a day was applied to experiment group,with a treating period of 12 weeks.NIHSS,modified Rankin,Barthel index,SS-QOL,and traditional Chinese medicine(TCM)symptom score were applied to evaluate the efficiency at 6,12 and 24 week.[Results]All the scores were improved in both groups after treating(P<0.05).The treatment group efficiency was 90.00%,and control group efficiency was 73.44%,there was significant difference between two groups(P<0.05).NIHSS,Barthel index and TCM symptom scores were better in experiment group than that in control group at week 12(P<0.05).NIHSS,Barthel index,SS-QOL,and TCM symptom scores were better in experiment group than that in control group at followed up to 24 week(P<0.05).Modified Rankin showed the same improvement in both groups(P>0.05).[Conclusions]Naoxueshuan tablets could significantly improve the symptoms and neural function,raise life quality of convalescent stroke of blood stagnation obstruction syndrome,with a definite curative efficiency,which should be spread and applied widely.

关 键 词：脑血栓片 中风病 瘀血阻络证 临床疗效 

分 类 号：R255.2[医药卫生—中医内科学]