左振素活血化瘀法治疗干燥综合征致肺间质纤维化的临床研究  

CLINICAL STUDY OF ZHENSU ZUO'EXPERIENCE ON TREATMENT OF PULMONARY INTERSTITIAL FIBROSIS CAUSED BY SJOGREN SYNDROME WITH PROMOTING BLOOD CIRCULATION TO REMOVE BLOOD

作　　者：耿玉青[1] 左振素[1] GENG Yu-qing;ZUO Zhen-su(Linyi City Hospital of traditional Chinese Medicine,Linyi 276002,China)

机构地区：[1]临沂市中医医院,山东临沂276002

出　　处：《山东医学高等专科学校学报》2018年第1期49-52,共4页Journal of Shandong Medical College

摘　　要：目的观察活血化瘀法治疗干燥综合征致肺间质纤维化的临床疗效。方法 80例干燥综合征所致肺间质纤维化患者,均为我院2014年9月~2016年9月期间收治的门诊和病房患者,将其随机分为两组。对照组患者口服羟氯喹0.2bid、雷公藤多甙20mg tid等治疗,研究组在对照组治疗的基础上加用活血化瘀方,每日一剂。两组患者均以治疗一个月为一疗程,连续治疗三个疗程。检测治疗前后两组患者6min步行试验(6MWT)、肺功能、临床表现、胸部CT变化。结果治疗结束后,与对照组比较,研究组患者6min步行试验评分及肺功能、临床表现均有明显改善,差异具有统计学意义(P<0.05);研究组患者胸部HRCT与对照组比较,差异无统计学意义(P>0.05)。结论左振素活血化瘀法可明显改善干燥综合征所致肺间质纤维化患者临床症状,提高患者生存质量,延缓肺功能下降速度,但不能明显改善患者胸部CT表现。Objective To observe the clinical effect of promoting blood circulation and removing blood stasis to treat pulmonary interstitial fibrosis caused by Sjogren's syndrome.Methods 80 cases of Pulmonary Interstitial Fibrosis caused by Sjogren Syndrome,Outpatients and ward patients were admitted to our hospital from September 2014 to September 2016.Subjects were randomly divided into two groups:Patients in the control group were treated with hydroxychloroquine 0.2 bid and tripterygium glycosides 20 mg tid;Study group in the control group based on the treatment of blood circulation with the addition of a day.Two groups of patients were treated for one month as a course of treatment,Continuous treatment of three courses.The 6-minute walking test(6MWT),lung function,clinical manifestations and chest CT were detected before and after treatment.Results After the treatment,compared with the control group,the study group 6 min walking test scores and pulmonary function,clinical manifestations were significantly improved,the difference was statistically significant(P<0.05);There was no significant difference in HRCT between the study group and the control group(P>0.05).Conclusion The method of Zhensu Zuo’experience of promoting blood circulation and removing blood stasis can obviously improve the clinical symptoms of patients with interstitial fibrosis caused by Sjogren's syndrome,improve the quality of life of patients and slow the rate of decline of lung function,but can not obviously improve the performance of chest CT.

关 键 词：活血化瘀法 干燥综合征 肺间质纤维化 临床表现 6min步行试验 肺功能 

分 类 号：R563[医药卫生—呼吸系统]