奥拉西坦联合盐酸多奈哌齐治疗血管性痴呆49例疗效及安全性评价  

Clinical Effect and Safety of Oxiracetam Combined with Donepezil Hydrochloride for Treating Vascular Dementia in 49 Cases

作　　者：沈展[1] 汪思阳[1] 沈婷婷[1] 王新 吴涛[3] 胡珺[1] Shen Zhan;Wang Siyang;Shen Tingling;Wang Xin;Wu Tao;Hu Jun;Hu Jun(Shanghai Xuhui Central Hospital,Shanghai,China 201100;Shanghai Xuhui Kangjian Community Health Service Center,Shanghai,China 201100;Changhai Hospital Affiliated to the Second Military Medical University,Shanghai,China 200433)

机构地区：[1]上海市徐汇区中心医院,上海201100 [2]上海市徐汇区康健社区卫生服务中心,上海201100 [3]中国人民解放军第二军医大学附属长海医院,上海200433

出　　处：《中国药业》2018年第4期50-52,共3页China Pharmaceuticals

摘　　要：目的探讨奥拉西坦联合盐酸多奈哌齐治疗血管性痴呆的疗效及安全性。方法选择医院2014年1月至2016年7月收治的血管性痴呆患者98例,采用随机序列表法分为观察组和对照组,各49例。两组患者均继续基础治疗,静脉滴注奥拉西坦注射液(每次4.0 g,每日1次),观察组患者在此基础上加服盐酸多奈哌齐片(每次5 mg,每日3次),21 d为1个疗程,均治疗3个疗程。结果观察组总有效率为93.88%,明显高于对照组的79.59%(P<0.05);与治疗前比较,两组患者简明精神状态量表(MMSE)中的定向力、语言表达力、注意力及计算力、记忆力及回忆力得分和总分均提高,且观察组提高更明显(P<0.05);与治疗前比较,两组患者长谷川痴呆量表(HDS)评分及日常生活活动能力量表(ADL)评分均显著升高,且观察组患者升高更显著(P<0.05);观察组与对照组患者不良反应发生率相当(34.69%比28.57%,P>0.05)。结论奥拉西坦联合盐酸多奈哌齐治疗血管性痴呆可显著提高临床疗效,并可明显改善患者的精神、认知功能、生活活动能力,且无严重不良反应,值得推广。Objective To investigate the clinical effect and safety of oxiracetam combined with donepezil hydrochloride for treating vascular dementia.Methods Totally 98 patients with vascular dementia admitted to our hospital from January 2014 to July 2016 were selected and randomly divided into the observation group and the control group,49 cases in each group.All patients were given basic treatment continually(intravenous injection of oxiracetam,4.0 g/time,once a day),on this basis,the patients in the observation group taken donepezil hydrochloride orally,5 mg/time,3 times a day,21 d for a course of treatment,both of the two groups were treated for 3 courses of treatment.Results The total effective rate of the observation group was 93.88%,which was significantly higher than 79.59%of the control group(P<0.05).After treatment,the scores of orientation,language expression,attention and calculation,memory and recall of the MMSE scale in the two groups were significantly higher than those before treatment(P<0.05),and those in the observation group were significantly higher than those in the control group(P<0.05).The HDS score and ADL score of the two groups were significantly higher than those before treatment,and those in the observation group were significantly higher than those in the control group(P<0.05)The incidence rate of adverse reactions in the two groups was similar(34.69%rs.28.57%,P>0.05).Conclusion Oxiracetam combined with donepezil hydrochloride for treating patients with vascular dementia can significantly improve the clinical efficacy,and it also has an obvious promoting effect on the patients'mental,cognition and viability without serious adverse reac-tion,which is worthy of promotion.

关 键 词：奥拉西坦 盐酸多奈哌齐 血管性痴呆 临床疗效 认知功能 生活活动能力 安全性 

分 类 号：R969.4[医药卫生—药理学] R971.92[医药卫生—药学]