血尿酸、血钙、血浆白蛋白的孕期改变与子痫前期联合预测的相关性  

Correlation between change of blood uric acid,serum calcium and plasma albumin during pregnancy and collaborative forecasting of preeclampsia

作　　者：杨林[1] 王亦雄[1] YANG Lin;WANG Yixiong(Yangzhou Maternal and Child Health Care Hospital,Yangzhou,Jiangsu,225001)

机构地区：[1]江苏省扬州市妇幼保健院,江苏扬州225001

出　　处：《实用临床医药杂志》2018年第7期70-73,共4页Journal of Clinical Medicine in Practice

基　　金：江苏省扬州市社会发展前瞻性研究项目(YZ2014223)

摘　　要：目的通过联合监测血尿酸、血钙、血浆白蛋白的孕期改变,研究与子痫前期的相关性。方法选取单活胎孕妇,其中诊断为妊娠期高血压疾病者128例,分为A组重度子痫前期患者66例、B组轻度子痫前期患者24例、C组妊娠期高血压患者38例,另随机选取68例正常妊娠孕妇为D组。联合监测4组三项指标的变化,预测子痫前期的发生与多因素的相关性。结果 (1)孕中期4组血钙、血尿酸、血浆白蛋白差异无统计学意义;孕晚期4组出现不同程度的变化,尤其是A组血钙、血尿酸、血浆白蛋白变化显著(P<0.05)。(2)孕晚期4组超过二项异常指标者比例有显著差异(P<0.05)。(3)孕晚期血钙、血尿酸、血浆白蛋白单项预测的灵敏度分别为42.7%、60.7%、65.4%,特异度分别为61.4%、64.7%、32.4%。三项联合预测时灵敏度为93.1%,特异度为86.7%,明显高于单项预测。结论孕期联合监测血钙、血浆白蛋白、血尿酸是子痫前期预测的一种有效方法。Objective To explore the correlation between change of blood uric acid,serum calcium and plasma albumin during pregnancy and collaborative forecasting of preeclampsia.Methods The pregnant women with single fetus were selected,and 128 patients with gestational hypertension disease were divided into group A(n=66,severe preeclampsia),group B(n=24,mild preeclampsia),and group C(n=38,gestational hypertension),and 68 normal pregnant women were selected as group D.The change of indicators in four groups was monitored,and correlation between the occurrence of preeclampsia and multiple factors was analyzed.Results There were no significant differences in serum calcium,plasma albumin,blood uric acid in the second trimester among the four groups.In the third trimester,the indexes changed significantly,especially in group A,the levels of serum calcium,blood uric acid and plasma albumin changed significantly(P<0.05).There were significant differences in ratio of patients with abnormity of over two indexes among the four groups(P<0.05).The sensitivities of serum calcium,plasma albumin and blood uric acid in the third trimester were 42.7%,60.7%and 65.4%respectively,and the specificities of those were 61.4%,64.7%and 32.4%respectively.The sensitivity of combination of three indexes was 93.1%and the specificity was 86.7%,which were significantly higher than the single index.Conclusion Combined monitoring of blood calcium,plasma albumin,and uric acid during pregnancy is an effective method for prediction of preeclampsia.

关 键 词：联合预测 子痫前期 血钙 血浆白蛋白 血尿酸 

分 类 号：R714.24[医药卫生—妇产科学]