米力农对肺动脉高压的治疗作用及其机制探究  

Study of milrinone therapeutic effect on pulmonary hypertension and its mechanism

作　　者：房大广[1] 崔春燕[1] 冯增斌[1] 夏嘉鼎[2] Fang Da-guang;Cui Chun-yan;Feng Zeng-bin;Xia Jia-ding(Department of cardiac surgery,Affiliated Hospital of Chengde Medical College,Chengde 067000,China;ICU,Affiliated Hospital of Chengde Medical College,Chengde 067000,China)

机构地区：[1]河北省承德医学院附属医院心脏外科,河北承德067000 [2]河北省承德医学院附属医院ICU,河北承德067000

出　　处：《东南大学学报（医学版）》2018年第1期83-86,共4页Journal of Southeast University(Medical Science Edition)

基　　金：河北省科技厅计划项目(152777205)

摘　　要：目的:观察不同剂量米力农对肺动脉高压患者的治疗作用,在此基础上探讨米力农的降低肺动脉高压的机制。方法:测定患者给药后平均体动脉压、肺动脉压、肺血管阻力、血清中肾素、血管紧张素、醛固酮水平和6分钟步行步数等指标。结果:与对照组相比3组患者肺动脉压力、平均体动脉压、肺血管阻力显著降低(P<0.01或0.05),同时能够显著性的提高6分钟步行步数(P<0.01或0.05)。高剂量组要明显优于中剂量组和低剂量组。3组给药组均能明显降低患者血清中肾素、血管紧张素Ⅱ、醛固酮水平,差异具有统计学意义(P<0.01或0.05)。结论:米力农能较好的缓解肺动脉高压,提高患者的肺功能。本研究为米力农的相关机制研究和临床实践提供了重要参考。Objective:To study the different doses effect of milrinone to the treatment of patients with pulmonary artery hypertension.Based on this,the mechanism of milrinone to pulmonary artery hypertension have been discussed.Methods:Mean arterial pressure,pulmonary artery pressure,pulmonary ascular resistance,serum renin,angiotensin and aldosterone levels and 6 minutes walk steps were detected after and before the treatment.Results:Compared with control group,pulmonary arterial pressure,mean arterial pressure,pulmonary vascular resistance in the patients of the three groups decreased significantly(P<0.01 or 0.05),and significantly improve steps of 6-minutes walk(P<0.01 or 0.01).The results in the high dose group was better than those middle dose group and low dose group.In terms of reducing serum renin,angiotensinⅡ,aldosterone levels with statistically significant difference(P<0.01 or 0.01).Conclusion:Milrinone can alleviate pulmonary hypertension,improve the patients lung function.This study for milrinone can make a example for mechanism research and clinical practice.

关 键 词：肺动脉高压 米力农 肾素 血管紧张素Ⅱ 醛固酮 

分 类 号：R543.2[医药卫生—心血管疾病]