不同胎龄及不同程度的呼吸窘迫综合征新生儿治疗后肺功能情况观察  

The pulmonary function of beonates with different gestational ages and different degrees of respiratory distress syndrome

作　　者：林报忠 郑通喜 周红艳[1] 李宇 LIN Baozhong;ZHENG Tongxi;ZHOU Hongyan(Department of Neonatology,Hospital for Maternal and Child Heath of Sanya City,Hainan,Sanya 572000,China)

机构地区：[1]海南省三亚市妇幼保健院新生儿科,572000

出　　处：《河北医药》2018年第7期1065-1067,共3页Hebei Medical Journal

基　　金：海南省医学科学研究重点课题(编号:琼卫2015 PT-38)

摘　　要：目的探讨不同胎龄以及不同程度的呼吸窘迫综合征(RDS)新生儿治疗后肺功能情况。方法 RDS新生儿158例,其中<34周早产儿96例、晚期早产儿32例、足月儿30例,依照RDS严重程度分为轻度RDS组121例,重度RDS组37例;并选择同期接诊的非RDS新生儿228例作为对照,其中<34周早产儿85例、晚期早产儿40例、足月儿103例。所有受试者在纠正胎龄44周时均检测肺功能[每千克体重潮气量(VT/kg)、呼吸频率(RR)、达峰时间比(TPEF/tE)、达峰容积比(VPEF/NE)]。结果 RDS组不同胎龄患儿肺功能指标比较差异均无统计学意义(P>0.05);和相同胎龄比较,RDS组TPEF/tE、VPEF/VE均明显比非RDS组低(P<0.05),2组VT/kg、RR比较差异无统计学意义(P>0.05);重度RDS组TPEF/tE、VPEF/VE明显比轻度RDS组和非RDS组低,轻度RDS组TPEF/tE、VPEF/VE明显比非RDS组低,差异均有统计学意义(P<0.05)。结论在RDS新生儿治疗后小气道仍有受阻现象存在,阻塞程度和RDS严重程度之间存在着密切的关系。Objective To observe the pulmonary function of beonates with different gestational ages and different degrees of respiratory distress syndrome(RDS).Methods A total of 158 neonates with RDS who were admitted and treated in our hospital from June 2014 to June 2016 were enrolled as research objects,in whom,there were 96 cases of premature infants whose age was less than 34 weeks,32 cases of late preterm infant,30 cases of term infant.According to the severity of RDS,these patients were divided into mild RDS group(n=121)and severe RDS group(n=37),at the same time,228 infant patients with non RDS were enrolled as control group,including 85 cases of premature infants(less than 34 weeks),40 cases of late preterm infants,103 cases of term infants.The pulmonary function indexes including tidal volume per kg of weight(VT/kg),respiratory rate(RR),time of peak ratio(TPEF/tE),volume ratio of peak(TPEF/NE)]at the corrected gestational age(44 weeks)were detected.Results There were no significant differences in lung function indexes of patients with different gestational ages in RDS group(P>0.05).The time of peak ratio(TPEF/tE)and volume ratio of peak(VPEF/VE)in RDS group were significantly lower than those in control group(P<0.05),however,there were no significant differences in tidal volume per kg of weight(VT/kg)and respiratory rate(RR)between the two groups(P>0.05).The TPEF/tE and VPEF/VE in severe RDS group were significantly lower than those in mild RDS group and the control group,moreover,the TPEF/tE and VPEF/VE in mild RDS group were significantly lower than those in control group(P<0.05).Conclusion There exists a small airway obstruction in neonates with RDS after treatment,moreover,the degree of obstruction is closely correlated with severity of RDS.

关 键 词：呼吸窘迫综合征 新生儿 肺功能 纠正胎龄 

分 类 号：R272.1[医药卫生—中医儿科学]