鼻咽癌常规放疗与适形调强放疗复发率及疗效比较  

Comparison of Recurrence Rate and Curative Effect of Conventional Radiotherapy and Conformal Radiotherapy for Nasopharyngeal Carcinoma

作　　者：吕心明 张应荣 张伟克[1] 薛递新 孙瑶瑶 LYU Xin-ming;ZHANG Ying-rong;ZHANG Wei-ke;XUE Di-xin;SUN Yao-yao(Department of Radiotherapy,Laigang Hospital Affiliated to Taishan Medical College,Laiwu,Shandong Province,271126 China;Finance Section,Bureau of Health and Family Planning,Shandong Province Laiwu Steel City,Laiwu,Shandong Province,271126 China)

机构地区：[1]泰山医学院附属莱钢医院放疗科,山东莱芜271126 [2]山东省莱芜市钢城区卫生和计生局财务科,山东莱芜271126

出　　处：《系统医学》2017年第18期109-111,共3页Systems Medicine

摘　　要：目的通过比较鼻咽癌患者采用常规放疗与适形调强放疗对患者复发率及疗效的影响,探讨鼻咽癌的最近放疗方式。方法选择了笔者所在医院2010年3月—2016年7月期间的鼻咽癌患者共100例,采用随机数字表法分为两组,每组50例,对照组50例患者采用鼻咽癌常规放疗,观察组50例患者采用适形调强放疗。两组患者随访1年以上,观察两组患者的放疗结束后的肿瘤消退率、肿瘤明显缩小率,放疗过程中出现口干与急性黏膜反应等不良反应的发生率,统计两组复发率。结果观察组患者肿瘤消退率46例(92%),显著高于对照组患者31例(62%),差异有统计学意义(P<0.05);观察组患者肿瘤明显缩小率21例(42%),显著高于对照组患者5例(10%),差异有统计学意义(P<0.05);观察组出现不良反应的发生率6例(12%),显著低于对照组14例(28%),差异有统计学意义(P<0.05);观察组患者1年复发率1例(2%)显著低于对照组11例(22%),差异有统计学意义(P<0.05)。结论对于鼻咽癌患者,与常规放疗相比,适形调强放疗降低了复发率,提高了临床疗效,值得在有条件的医院推广应用。Objective This paper tries to compare the effect of conventional radiotherapy and conformal radiotherapy(IMRT)on the recurrence rate and curative effect of nasopharyngeal carcinoma(NPC),and to explore the latest radiotherapy modalities for nasopharyngeal carcinoma(NPC).Methods A total of 100 cases of patients with nasopharyngeal carcinoma in this hospital from March 2010 to July 2016 were randomly divided into two groups,with 50 cases in each group,the control group was treated with nasopharyngeal carcinoma,the observation group was treated with imrt.Two groups of patients were followed up for 1 year,the tumor regression rate,significant tumor shrinkage rate,adverse reactions and acute mucosal reactions such as dry mouth during radiotherapy for the incidence of adverse reactions of radiotherapy of the two groups of patients after radiotherapy were observed.Results The tumor regression rate of the observation group was 46 case(92%),significantly higher than the control group of 31 case(62%),there was significant difference(P<0.05);the patients in the observation group were significant decrease in tumor size of 21 case(42%),significantly higher than the control group of 5 case(10%),there was significant difference(P<0.05);the incidence rate of adverse reactions in the observation group was 6 case(12%),significantly lower than the control group of 14 case(28%),there was significant difference(P<0.05);recurrence rate of the patients in the observation group for 1 year was 1 case(2%),significantly lower than the control group of 11 case(22%),there was significant difference(P<0.05).Conclusion Compared with conventional radiotherapy,conformal intensity-modulated radiotherapy reduces the recurrence rate and improves the clinical efficacy in nasopharyngeal carcinoma.It is worth popularizing in the qualified hospitals.

关 键 词：鼻咽癌 常规放疗 适形调强放疗 复发率 临床疗效 

分 类 号：R730.55[医药卫生—肿瘤]