非哺乳期乳腺炎患者血液中自身抗体和免疫指标的变化及意义  

Changes in Autoantibodies and Immune Indexes and Their Clinical Significance in Blood of Patients with Non-Lactational Mastitis

作　　者：李爱辉 李洪 王力斌 欧阳杰 LI Ai-hui;LI Hong;WANG Li-bin;OU YANG Jie(Department of Surgical Oncology,Donghua Hospital of Dongguan,Dongguan 523110,China)

机构地区：[1]东莞市东华医院肿瘤外科,广东东莞523110

出　　处：《实用临床医学（江西）》2018年第2期38-39,52,共3页Practical Clinical Medicine

摘　　要：目的分析非哺乳期乳腺炎患者血液中自身抗体和免疫指标的变化,探讨该病是否与自身免疫性疾病相关。方法选择80例非哺乳期乳腺炎女性患者为观察组,同时以80例健康女性为对照组,对2组抗组蛋白抗体(AHA)、抗核抗体(ANA)、免疫球蛋白A、G、M(IgA、IgG、IgM)及补体水平(外周血C3、C4)多个免疫指标进行检测。结果观察组AHA、ANA阳性率分别为40.00%、66.25%,显著高于对照组的3.75%、6.25%(P<0.05);观察组免疫球蛋白IgA、IgG、IgM,C4补体水平及总补体水平均高于对照组(P<0.05),C3补体水平与对照组相近(P>0.05)。结论非哺乳期乳腺炎可能是一种存在部分免疫功能紊乱的自身免疫性疾病。Objective To analyze the changes in autoantibodies and immune indexes in blood of patients with non-lactational mastitis,and to explore the correlation between non-lactational mastitis and autoimmune disease.Methods The levels of anti-histone antibodies(AHA),antinuclear antibodies(ANA),immunoglobulins(IgA,IgG,IgM)and complements(C3,C4)were measured in 80 patients with non-lactational mastitis(observation group)and 80 healthy women(control group).Results The positive rates of AHA and ANA in observation group were respectively 40.00%and 66.25%,significantly higher than those in control group(P<0.05).Moreover,IgA,IgG,IgM,C4 complement and total complement levels in observation group were higher than those in control group(P<0.05).There was no significant difference in C3 complement level between the two groups(P>0.05).Conclusion Non-lactational mastitis may be an autoimmune disease with partial immune dysfunction.

关 键 词：非哺乳期乳腺炎 自身免疫性疾病 抗组蛋白抗体 抗核抗体 免疫球蛋白 补体 

分 类 号：R655.8[医药卫生—外科学]