阿卡波糖对2型糖尿病患者血脂及尿酸代谢的研究  

Research on Effect of Acarbose on the Blood Liquid and Uric Acid Metaboli sm of Patients with Type 2 Diabetes

作　　者：郑淑红[1] 孙小力[1] 张滨 赵欣[1] 王云枫[3] 郭长秀[3] ZHENG Shu-hong;SUN Xiao-li;ZHANG Bin;ZHAO Xin;WANG Yun-feng;GUO Chang-xiu(Mudanjiang Medical College,Mudanjiang,Heilongjiang Province,157001 China;Department of Endocrinology,Gannan Hospital of TCM,Qiqihar,Heilongjiang Province,162100 China;Department of Endocrinology,Hongqi Hospital of Mudanjiang Medical College,Mudanjiang,Heilongjiang Province,157001 China)

机构地区：[1]牡丹江医学院,黑龙江牡丹江157001 [2]甘南县中医院内分泌科,黑龙江齐齐哈尔162100 [3]黑龙江牡丹江医学院红旗医院内分泌科,黑龙江牡丹江157001

出　　处：《糖尿病新世界》2017年第24期27-29,33,共4页Diabetes New World Magazine

摘　　要：目的探讨阿卡波糖对2型糖尿病(T2DM)患者血脂及尿酸代谢的影响。方法选取2016年10月—2017年8月收治的T2DM患者200例,按奇偶数分为对照组、实验组,两组均给予糖尿病饮食管理和运动治疗,对照组给予二甲双胍治疗,实验组给予阿卡波糖治疗,持续服药12周。观察治疗前后空腹血糖(FPG)、餐后2 h血糖(2 hPFG)、糖化血红蛋白(HbA1c)、血脂(甘油三酯TG、总胆固醇TC、低密度脂蛋白胆固醇LDL-C、高密度脂蛋白胆固醇HDL-C)、尿酸(UA)的水平变化。结果实验组治疗后BMI、FPG、2 hPFG、HbA1c、TG、TC、LDL-C、UA较治疗前明显下降,HDL-C较治疗前明显升高,差异有统计学意义(P<0.05);对照组治疗后BMI、FBG、2 hPFG、HbA1c较治疗前下降(P<0.05),TG、TC、LDL-C、UA较治疗前无明显下降,HDL-C无升高,差异无统计学意义(P>0.05)。两组治疗后BMI、FPG、2 hPFG、TC、LDL-C、HDL-C、UA差异有统计学意义(P<0.05)。结论阿卡波糖和二甲双胍均可降低BMI、FPG、2 hPFG、HbAlc的水平,但两组HbAlc无明显差异。此外,阿卡波糖还可以降低TG、TC、LDL-C、UA的水平,升高HDL-C的水平。可知,阿卡波糖可以明显改善血脂及尿酸的代谢,早期预防T2DM慢性并发症及延缓心脑血管病的进展。Objective To study the effect of acarbose on the blood liquid and uric acid metabolism of patients with type 2 diabetes.Methods 200 cases of T2DM patients from October 2016 to August 2017 were selected and randomly divided into two groups,both groups used the diabetes dieting management and motor therapy,and the control group were treated with melbine,while the experimental group were treated with acarbose,for 12 weeks in a row,and the changes of FPG,2 hPFG,HbA1c,TG,TC,LDL-C,HDL-C,UA before and after treatment were observed.Results After treatment,the BMI,FPG,2 hPFG,HbA1c,TG,TC,LDL-C,UA obviously decreased compared with those before treatment,and the HDL-c obviously increased compared with that before treatment,with statistical significance(P<0.05),after treatment,the BMI,FBG,2 hPFG,HbA1c decreased compared with those after treatment(P<0.05),and the TG,TC,LDL-c,UA had no obvious decrease compared with those before treatment,and the HDL-c had no increase,without statistical significance(P>0.05),after treatment,the differences in the BMI,FPG,2 hPFG,TC,LDL-C,HDL-C,UA between the two groups were obvious,with statistical significance,The acarbose and melbine can reduce the levels of BMI,FPG,2 hPFG,HbAlc,Howerev,there was no significant difference between the two groups of HbAlc,(P<0.05).The acarbose and melbine can reduce the levels of BMI、FPG、2 hPFG、HbA1c、Howerer,there was no significant difference between the two groups of HbA1c.Conclusion The acarbose and melbine can reduce the levels of TG,TC,LDL-C,UA,and increase the HDL-C level,therefore,the acarbose can obviously improve the blood liquid and metabolism of uric acid,and the early prevention of T2DM chronic complications can prolong the progress of cerebrovascular diseases.

关 键 词：阿卡波糖 2型糖尿病 血脂 尿酸 

分 类 号：R587[医药卫生—内分泌]