异基因造血干细胞移植治疗继发性噬血细胞综合征后ABO血型转变时间的探讨及文献复习  

Clinical analysis on conversion of blood group in secondary hemophagocytic syndrome with allogenetic-hematopoietic stem cell transplantation and literature review

作　　者：苏瑞蕊[1] 付丽[1] 董鹏[1] SU Rui-rui;FU Li;DONG Peng(Department of Blood Transfusion,Beijing Friendship Hosipital,Capital Meidcal Unversity,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院输血科,北京100050

出　　处：《临床和实验医学杂志》2018年第7期777-780,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨继发性噬血细胞综合征接受异基因造血干细胞治疗后发生血型转变的时间。方法回顾性分析3例继发性噬血细胞综合征患者,观察其接受基因造血干细胞移植后血型转变的成功时间、白细胞和血小板植活时间。结果 3例患者分别在移植后12天、24天、28天血型转变成功,在移植后12天、13天、15天白细胞植活,在移植后16天、10天、14天血小板植活。结论继发性噬血细胞综合征的患者接受异基因造血干细胞治疗后,需要密切监测ABO复检检测和ABO抗体滴度检测,从而有助于及时反馈患者血型的正反定变化,指导红细胞、血浆和血小板的正确输注以避免溶血。Objective To explore the conversion time of blood group in patients with secondary hemophagocytic syndrome treated by allogenetic-hematopoietic stem cell transplantation.Methods The clinical data of three cases with ABO-incompatible allogeneic hematopoietic stem cell transplantion were revewed and followed up in order to observe and evaluate the engraftment period for red blood cells,white blood cells and platelets.Results After the transplantation therapy,the conversion periods for blood groups were 12 d,24 d and 28 d,the engraftment periods for white blood cells were 12 d,13 d and 15 d and for platelets were 16 d,10 d and 14 d respectively.Conclusion The clinical surveillance of engraftment time and titers of ABO blood group antibodies are necessary for blood replacement in patients with secondary hemophagocytic syndrome,they are important for correct selection of blood products and avoidance of hemolysis.

关 键 词：继发性噬血细胞综合征 异基因造血干细胞 细胞移植 血型转变 

分 类 号：R457.7[医药卫生—治疗学] R55[医药卫生—临床医学]