心血管疾病PET显像剂研究进展  

Progress of PET Imaging Agents for Cardiovascular Diseases

作　　者：马慧 梁宏[1] 徐万帮[2] 唐刚华[1] MA Hui;LIANG Hong;XU Wan-bang;TANG Gang-hua(Guangdong Engineering Research Center for Translational Application of Medical Radiopharmaceuticals and Department of Nuclear Medicine, The First Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510080,China;Guangdong Institute of Drug Control,Guangzhou 510180,China)

机构地区：[1]中山大学附属第一医院广东省医用放射性药物转化应用工程技术研究中心核医学科,广东广州510080 [2]广东省药品检验所,广东广州510180

出　　处：《同位素》2018年第2期114-122,共9页Journal of Isotopes

基　　金：国家自然科学基金(81571704;81671719);广东省自然科学基金(2015A030313067);广东省科技计划项目(2013B021800264);广州市科技计划项目(201604020169)

摘　　要：正电子发射断层(PET)显像可用于监测非侵袭性心血管病变,有良好的临床应用前景。各种显像剂的转化应用使PET从分子水平上早期发现和评估心血管疾病,提高了心血管疾病早期诊断和疗效监测的灵敏度和特异性。本文介绍了用于心血管疾病的PET显像剂及其应用进展。Positron emission tomography(PET)imaging has successfully allowed the noninvasive detection of cardiovascular disease and shows good clinical application prospects.Development and translation application of various imaging agents furtherly enable PET imaging to be used for early detection and progression evaluation of cardiovascular diseases at molecular level,which can improve sensitivity and specificity of early diagnosis and monitoring of the diseases.This review mainly describes development and application progression of PET tracers for cardiovascular diseases imaging.

关 键 词：心血管疾病 正电子发射断层(PET) 放射性示踪剂 

分 类 号：TL923[核科学技术—核燃料循环与材料] R817.4[医药卫生—影像医学与核医学]